I have been on Nexium/Prilosec for about six years (due to heartburn related GERD) and in those six years I have had no heartburn and very very few instances of reflux - less than a half dozen for sure.
Today however I was a bad boy - real bad. I ate spicy Mexican at lunch with a caffeinated carbonated drink and then tonight I had a big steak with steak fries and three glass of caffeinated tea. Yes I know these are not good GERD meals but man they were good. :D Anyway, I had some regurgitation when I burped. I could feel it come into the back of my throat but it didn't burn or anything - just a wet burp. This is the first time I have had anything like this in probably 3 or 4 years. I usually don't eat this bad to be honest. Again, didn't burn my chest or throat at all - just wasn't pleasant.
Anyway, I guess since PPIs only stop acid production and not cure the flap problems this is a results of my weakened lower esophageal sphincter allowing reflux and not an indication that the PPIs are not working? I think everyone has a "wet burP" sometimes but since I can't remember the last time I had one it sort of bugs me