PPIs and H2 Antagonists

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Date Joined Mar 2011
Total Posts : 40
   Posted 3/9/2011 6:53 AM (GMT -6)   
I've heard that you can take these together and that you can't. By together I mean a PPI in the morning and Ranitidine in the evening. I've heard that this can work well, but I've also heard that if you take Ranitidine in the evening it will stop the PPI working the next day. Anyone throw any light on this?

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Date Joined Feb 2009
Total Posts : 7180
   Posted 3/9/2011 9:02 AM (GMT -6)   
Hi katlan,
The information you're getting doesn't match what my doctors have recommended.

From the time my reflux got much worse, my family doctor (and asthma doctor) recommended Ranitidine (Zantac) 300mg at bedtime in addition to Protonix 40mg morning and night.

Using both can be more effective than one with patients who aren't responding to just PPI's. They reduce acid in different ways, so they don't really override.

The Ranitidine is not time released, so it's something to be taken right when you go to sleep.

I've taken it in the morning instead of a PPI when I've tried to reduce my PPI usage.

Have you discussed this with your doctor? You doc may have a different opinion, but three of my doctors concur that this is an effective and safe treatment.

Good luck!

Regular Member

Date Joined Mar 2011
Total Posts : 40
   Posted 3/9/2011 9:12 AM (GMT -6)   
Thanks Denise, the last doc I spoke to and the pharmacist were adamant that you couldn't be prescribed them together in any combination. Kat x

Regular Member

Date Joined Feb 2011
Total Posts : 46
   Posted 3/9/2011 12:21 PM (GMT -6)   
My experience matches Denise's. I take Dexilant 60mg in the morning and have a prescription for Zantac at night has needed. So far, I've only needed it twice, but the doctor and pharmacist both said it's fine to take Dexilant and Zantac together.

Regular Member

Date Joined Mar 2011
Total Posts : 40
   Posted 3/9/2011 1:44 PM (GMT -6)   
Thanks for your replies. Kat x

Elite Member

Date Joined Jul 2009
Total Posts : 14475
   Posted 3/9/2011 3:59 PM (GMT -6)   
I was on a nexium at morning and at dinner. Then zantac at night.
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