On PPIs? Symptoms of low magnesium. Research paper.

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Veteran Member

Date Joined Oct 2009
Total Posts : 5028
   Posted 3/14/2011 4:26 PM (GMT -6)   
A new research paper says long term PPI use, at least 3 months but more likely after a year or more, may cause us to have low magnesium levels.
  "Serious events included tetany, seizures, tremors, carpopedal spasm, atrial fibrillation, supraventricular tachycardia, and abnormal QT interval. Impaired parathyroid hormone secretion associated with hypomagnesemia may also cause hypocalcemia."
This does NOT mean go out and start taking a bunch of magnesium!  It means ask your doctor about getting a blood test if you have any symptoms, or even before taking PPIs if you are on any of the drugs listed in the article.

New Member

Date Joined Mar 2011
Total Posts : 8
   Posted 3/22/2011 10:44 PM (GMT -6)   
Oh, but there are so very, very many reasons everyone already should be taking a magnesium supplement. Besides which, Mg prevents and treats heartburn as well as any proton pump inhibitor (PPI) as well. Really it is nothing less than the whole rationale behind PPIs that should be under question, as it is almost always low Mg intake that is responsible for heartburn in the first place!

The list of disease conditions that are caused or aggravated by low Mg is astoundingly long. Just the length of it and fact that you never hear of Mg in relation to these diseases is enough to make one suspect some sort of massive drug company conspiracy. Here is but a partial list: ADD, AGING, anger/aggression, all addiction (especially alcoholism), allergies, ALS, Alzheimer's, anxiety, arthritis, asthma, atherosclerosis, autism, bruxism, CANCER, carpel tunnel, chemical sensitivity, chronic fatigue, constipation, depression, diabetes, epilepsy, eclampsia, fibromyalgia, hearing loss, heart disease, hypertension, impatience, insomnia, kidney stones, metabolic syndrome (and perhaps all obesity), migraine headache, mitral valve prolapse, menopause, multiple sclerosis, nail biting, OCD, osteoporosis, peripheral vascular disease, PMS, many psychiatric disorders, PTSD, SIDS, sickle cell disorder, STRESS, stuttering, tinnitus, TMJ, and toxic shock. And this is by no means all disorder related to low Mg levels.

Perhaps the most common denominator of many of these disorders is poor nerve function. Mg improves nerve signalling among other things--particularly reducing excessive signalling (excess nerve function/nervousness is exacerbated by common dietary calcium excess). Another huge function is to decrease peroxynitrite nitrosation, this is a particularly important means of cellular damage throughout the body. Nitrosation is now thought to be likely the most damaging pathway of free radical oxidative damage.

Blood tests for Mg are notoriously inaccurate, failing to detect low Mg levels until they are quite dangerously low. This is because the body regulates blood levels very tightly drawing Mg from other tissues. A more accurate measure tests a sizable tissue sample, which is considerably more invasive.

And there is less and less Mg in the Western diet, but more and more competitive factors, which include everything we like to eat (from sugar, fats and phosphate to the most common vitamins). PPI induced Mg loss is but a tiny additional reason that everyone should be taking Mg for pretty much every health reason one can imagine.

Regular Member

Date Joined Feb 2011
Total Posts : 46
   Posted 3/23/2011 10:09 AM (GMT -6)   
This message has been brought to you by the Magnesium Producers' Association of America.

Seriously, please support the following claims:

1) "Mg prevents and treats heartburn as well as any proton pump inhibitor (PPI)."

2) "it is almost always low Mg intake that is responsible for heartburn in the first place!"
Sorry for edit,  I reread your post and understand what you were saying.

Post Edited By Moderator (stkitt) : 3/24/2011 9:11:21 AM (GMT-6)

New Member

Date Joined Mar 2011
Total Posts : 8
   Posted 3/23/2011 9:31 PM (GMT -6)   
Haha, that may be fair. I am definitely very enthusiastic about magnesium these days. The people who have been to my house lately have referred to it as "magnesium university." Tho, I do not make anything from magnesium and have not invested in it any more than my own few bottles. And I only discovered its myriad health benefits after discovering what benefit my sister who has trauma-induced epilepsy found in it making her seizures again responsive to her medication. Then I tried it and liked it myself too. Your skepticism is perfectly understandable. I definitely would not have believed it myself. And I certainly did not provide the refs in my post to make even an argument I'd have found credible before I learned what I now know. Here are a couple of general references about Mg in nutrition: http://www.mgwater.com/human.shtml http://www.mgwater.com/dietary.shtml both authored by Mildred Seelig, MD. She proposed the Mg RDI should really be 7-10 mg/kg/day for men (450-600 mg/day) and 6 mg/kg/day for women (360 mg) with up to 15 mg/kg/day for healing/tissue repair. And here's a ref about Mg for acid reflux:

My assertion that it is probably just low Mg intake that is responsible for acid reflux was the combination of the facts that even the USDA has said 70% of peoples' diets (>95% by others' measures) are Mg deficient (by the current RDI) and the well known fact that Mg is alkaline and as such a very fast acting antacid. If you will just try to have acid reflux on magnesium, you'll see what I mean. It neutralizes stomach acid instantly. Additionally, in my own unscientific, limited experience, the people I know who had had acid reflux and tried magnesium said they did not even need to take their PPI anymore (pepcid, prilosec, prevacid--only three people). And in all cases, they found magnesium had unexpectedly helped with other conditions as well (blood sugar control, high blood pressure, back pains, headaches, stress, and/or impatience).

It really is astounding how much good magnesium does for health in so very many ways. My main--if overstated--point was just that there is so much more reason to take Mg than just the deficiency that PPIs cause.

Also, the main reason for not using magnesium is its laxative effect, but there are forms that are completely nonlaxative. Mg malate and Mg glycinate are nonlaxative and are not compounded with excitatory amino acids (like aspartate and glutamate). It is mostly just Mg oxide/hydroxide and Mg citrate that are laxative (they're sold at all drug stores for their laxative effect). Additionally they are laxative just because they are so poorly absorbable.

Veteran Member

Date Joined Oct 2009
Total Posts : 5028
   Posted 3/24/2011 9:01 AM (GMT -6)   
I'll apologize up front because I am disagreeing in part with McMg's information. I wouldn't say anything at all, but it was my thread. I don't mean to be disrespecful, although I may come off that way. I truly appreciate information posted, even if I happen not to agree with it! I'm just a grandma now, even though I once worked in pharmacological research.

I skimmed the references provided above. I noted that the "complete book" and 1st paper references dated from the '40s through the early '70s. The second paper listed only daily requirements, references from the '90s. The third reference was a blog from a "health advocate." I looked at the books for sale, couldn't find any scientific research. The 4th reference by Dr. Hyman had a lot of claims that made sense, with apparent citations from scientific sources. None of the references supported the first post claims, although the second post claims are in them.

I hope that McMg will post again with support for the claims that low Mg is related to cancer, etc. I will read them!

I maintain that one should be under a doctor's care and taking his/her advice before taking ANY herbals and supplements!

New Member

Date Joined Mar 2011
Total Posts : 8
   Posted 3/24/2011 9:46 AM (GMT -6)   
In quick reply about cancer (because I only have a minute now), here are a few links:
http://www.mgwater.com/cancer.shtml <-- Mildred Seelig is my favorite.

In physiology & theory, Mg reduces peroxynitrite nitrosation damage, which is likely the biggest means by which free radical damage gets out of control. (Nitrosation disables SOD.)

It's also pretty important to note that "magnesia" magnesiums (oxide and hydroxide) are not at all the same as absorbable forms (which are mostly just amino acid chelates and Kreb's cycle acid conjugates). Because oxide & hydroxide are (usually) so poorly absorbed, it can actually decrease one's Mg level. Citrate is fairly poorly absorbable too. I tried these forms first, and they just gave me a headache--probably from dehydration.

New Member

Date Joined Mar 2011
Total Posts : 8
   Posted 3/24/2011 9:54 AM (GMT -6)   
There isn't a lot about Mg with specific reference to GERD that I've found yet, but here's a little bit:

http://www.ncbi.nlm.nih.gov/pubmed/19140217 "The aim of this study was to compare the concentrations of magnesium and calcium in exhaled breath condensate (EBC) of children with asthma and gastroesophageal reflux disease (GERD). [...] the magnesium to calcium ratio was statistically significantly lower in both GERD and asthma children as compared with control group."

And here are a couple Russian articles that say Mg-rich mineral water sped recovery or helped with GERD (and attendant cardiovascular disease).
http://www.ncbi.nlm.nih.gov/pubmed/17201221 "Drinking of sulphate-magnesium-calcium water by patients with gastroesophageal reflux disease of the first degree with cardial manifestations has a prokinetic and anti-inflammatory action leading to attenuation of gastroesophageal reflux and positive cardiovascular changes. Marked therapeutic efficacy of the water is due to specific action of magnesium ions having membrane-stabilizing, sedative effects, pronounced prokinetic and sympatholytic actions which manifest with weakening of ergotropic actions, higher efficacy of cardiac activity. These convert to a noticeable clinical response--regress of clinical symptoms and potentiation of anti-arrhythmic effects."

http://www.ncbi.nlm.nih.gov/pubmed/16404920 "Thirty patients with duodenal ulcer in remission running in combination with gastroesophageal reflux disease (GERD) were divided into two groups. Patients of group 1 received medication (omeprasol 20 mg twice a day, motilium 10 mg 3 times a day) and mineral water Klyuchi (200 ml 3 times a day). Patients of group 2 received the same medication but no mineral water. The efficacy of the treatment was assessed by the data obtained at esophagogastroduodenofibroscopy, morphological study of gastric and esophageal biopsies, 24-h pH-metry of the esophagus and the stomach. The results suggest that the addition of mineral water Klyuchi to standard medication of GERD shortens correction of clinical, endoscopic and morphological manifestations of the disease."

Also, if Candida truly is involved (as I've seen hypothesized), there are numerous reasons to believe Mg would help that too--it helps with yeast infection of all sorts. And there are probably as many reasons to believe it would help overcome H. pylori infection too, which I've seen is involved with GERD in a large number of cases.

Elite Member

Date Joined Apr 2007
Total Posts : 32602
   Posted 3/24/2011 10:21 AM (GMT -6)   
Just a reminder, Sharing information is allowed, but the forums are not to be used to publish articles. It is an improper use of critical forum resources. 
If you feel strongly about a topic a post with a few links to articles is allowed. Alcie's thread was short and she shared an article that she found helpful. 
Everyone is entitled to their opinion but please do review the forum rules.
Thank you for your understanding. 

Moderator: Anxiety/Panic, Osteoarthritis, GERD/Heartburn and Heart/Cardiovascular Disease.

"If you can't change the world, change your world"

Veteran Member

Date Joined Oct 2009
Total Posts : 5028
   Posted 3/24/2011 10:38 AM (GMT -6)   
Sorry Kitt -
It's my fault for asking for more references. I should have asked privately and I'll list my email next time. Mc wasn't publishing, just providing links to mostly government webpages. I will read them! I greatly appreciate that the posts are monitored! It's a lot of work. Thanks for correcting us.
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