Bethanechol strengthens the LES and chocolate weakens it

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mock turtle
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Date Joined Mar 2011
Total Posts : 467
   Posted 5/30/2011 11:52 AM (GMT -6)   
benthanechol is commonly used to strengthen the bladder muscle to aid urination but as reported here an off book use is sometimes found for helping the les !!

http://www.webmd.com/drugs/drug-8620-Bethanechol+Chloride+Oral.aspx?drugid=8620&drugname=Bethanechol+Chloride+Oral

and heres an interesting reference to chocolate weakening the les and then benthanecol reversing the effects of chocolate !

http://www.ncbi.nlm.nih.gov/pubmed/239592

edited to correct spelling in subject title!...me stupid

Post Edited (mock turtle) : 5/30/2011 7:23:47 PM (GMT-6)


mudmagnetmum
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Date Joined Apr 2011
Total Posts : 1604
   Posted 5/30/2011 3:28 PM (GMT -6)   
Interesting research you've dug up from 1975. I think it's a shame that the "success" of the drug industry means lots of these little things don't get revisited.

Wonder if chocolate is as bad as drinking chocolate; one of the few things that settles my stomach is hot chocolate made with soya milk but I do always wonder if it's not helpful overall. Wonder if any of the research shows how long the effect on the LES lasts? If they could just mix the drug and the chocolate together into a nice over the counter preparation we'd all be happy :-)

Hope you're feeling better now,
New stuff: GERD. Interstitial Cystitis
Lifelong stuff: Food allergies, eczema, asthma

mock turtle
Regular Member


Date Joined Mar 2011
Total Posts : 467
   Posted 5/30/2011 8:22 PM (GMT -6)   
mudmagnetmum

agreed it is a shame that pharma and some docs seem to push the latest "best" thing where as some of the older off label remedies from by-gone days dont get the play time deserrved

and the neat thing about benthanechol (if this is true...if) is that it appears to not one of the gastro prokinetics that present a minor but significant risk side effect of tardive dyskinesia. like metoclopramide which is an antiemetic

(bethanechol is a parasympathomimetic choline ester)

and when i looked up the two molecules they didnt seem to be related, but im no chemist so what do i know

since im tryin my best to cycle off of PPIs to an extended piece of time (im not against ppi s in all cases, they have their place) bethanechol may be an option...or if i could get the doc to prescribe it...baclofen

Post Edited (mock turtle) : 5/30/2011 7:25:18 PM (GMT-6)


stkitt
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Date Joined Apr 2007
Total Posts : 32602
   Posted 6/1/2011 3:24 PM (GMT -6)   
 
Interesting articles...............I am a love of chocolate and have been eating it for 62 years - My LES should have disappeared by now.  Just kidding. smhair
Kitt

~~Kitt~~
Moderator: Anxiety/Panic, Osteoarthritis, GERD/Heartburn and Heart/Cardiovascular Disease.
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"If you can't change the world, change your world"

mock turtle
Regular Member


Date Joined Mar 2011
Total Posts : 467
   Posted 6/1/2011 6:12 PM (GMT -6)   
kitt

i must admitt..i "cheat" every once in a while

i try to pick a time thats strategic in between meals and only eat a little and hope it doesnt come back to bite me on the next meal or that night.. and btw.ive loved chocolate for as long as you have ;)

oh and hey i found another anti reflux drug from long ago...im reading on the tubz that erythromycin also strengthens the les

http://www.ncbi.nlm.nih.gov/pubmed/8311129

Abstract
".... Erythromycin has a motilin-like effect on the stomach and significantly increases the lower esophageal sphincter (LES) pressure in normal volunteers. This investigation was performed to evaluate the effects of erythromycin on esophageal function in patients with gastroesophageal reflux disease (GERD). Esophageal manometry was performed in 10 GERD patients before and after intravenous infusion of 500 mg of erythromycin. Values are expressed as mean +/- SEM. LES pressure increased from 13.9 +/- 2.9 mm Hg at baseline to 28.9 +/- 3.6 mm Hg after infusion of erythromycin (p < 0.01). The duration of contractions in the proximal, middle, and distal esophagus was significantly prolonged

..... (1) Erythromycin profoundly stimulates the defective LES in patients with GERD. This appears to be a direct motilin agonist-like effect rather than being mediated by release of endogenous motilin. (2) Erythromycin has less effect on the esophageal body, although it does prolong the duration of esophageal contractions...."

wow amazing

PMID:
8311129
[PubMed - indexed for MEDLINE]

mudmagnetmum
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Date Joined Apr 2011
Total Posts : 1604
   Posted 6/1/2011 6:20 PM (GMT -6)   
All very interesting. Do you think the things that could help the LES tighten would still be effective if you have a small hernia? I see the the weak valve and the hernia as a bit of a "chicken and egg" type situation; does the slack valve let the hernia happen? If so does the hernia go away if the valve gets tightened by pharmaceutical means? ?
New stuff: GERD. Interstitial Cystitis
Lifelong stuff: Food allergies, eczema, asthma

mock turtle
Regular Member


Date Joined Mar 2011
Total Posts : 467
   Posted 6/1/2011 6:25 PM (GMT -6)   
mudmagnetmum

i suspect so but dont know for sure

i bet distention comes into play here...stuff enough into the stomach and no amount of les tightening is going to overcome the distortions that the weight and elongation put on the hernia

but a moderate meal on an average to small hiatal hernia...could work out alright

id like to try it with a lower dose... oral rather than iv.... if my doc will allow
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