The package says to wait two hours before or two hours after taking any kind of medication.
I questioned these directions with a pharmacist and she said that generally any medication you take will not take a full two hours to empty out of yoru stomach, so you can play with that number a bit more...perhaps take the med and wait an hour/fifteen or an hour and a half before taking Carafate.
She said that it was really important to take the Carafate the full two hours before meds, though. Otherwise the medications you take will not be absorbed properly.
Also, I believe you need an hour in between Carafate and antacids like Maalox.
I have taken Carafate as needed for years and have experienced no side effects. My family doctor said that it was good Carafate worked for me, because it is a very benign drug, and pretty much passes out through the GI tract without much of anything being absorbed.
I have a reactive stomach, and I really appreciate the long lasting coat of protection that Carafate Suspension puts on my wrap and stomach when they're irritated. I never want to be without it, just in case!