PPI/H2 side effects

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Regular Member

Date Joined Apr 2011
Total Posts : 377
   Posted 7/2/2011 8:50 PM (GMT -6)   
I am trying to treat my LPR without the meds as I get side effects from the PPIs/H2s:
Side effect symptoms: Tingling of the nerves / muscles all over the body (legs, near the knees, arms, back) - followed by body ache, knee pain etc. On some other PPIs I get insomnia, light headedness, nausea etc. I am a fit individual who used to workout regularly and always ate healthy and on time. So, changing my diet and lifestyle is not really helping me much .. as there is nothing much to change (except to avoid tomatoes, choc, coffee and alcohol).

One theory is that some sort of nerve related injury or inflammation has caused my LPR and for that I am taking neurontin and (sometimes) klonopin - but it isn't helping me that much (after about 6 weeks or so .. I still have LPR symptoms .. which seem to be going down a bit .. but not by a whole lot).

I am curious to know if anyone has successfully treated their LPR symptoms without the meds? Everywhere I look on the internet, 2x / day PPIs seems to be the only known "cure" for LPR!

Elite Member

Date Joined Jul 2009
Total Posts : 14475
   Posted 7/2/2011 9:02 PM (GMT -6)   
Surgery is the only thing that helped me.

Regular Member

Date Joined Apr 2011
Total Posts : 377
   Posted 7/2/2011 9:10 PM (GMT -6)   
Since my LES pressure is normal - close to 25mmHg, transient relaxations of the LES (TLESrs) is the only other probable cause for my reflux - and as to why the TLESrs are occuring- some theories include:
- some sort of neurological issue that is causing these TLESrs.
- anxiety / stress (depression) about unable to take the medication and therefore a feeling that this will never end.

I've been told that in such a scenario, surgeons are not likely to want to operate on me since I am not a candidate .. or rather too risky a candidate ... Further, I've been suffering for "only" about 4 months now .. so will have to give it more time before exploring the 'surgery' option ...

Forum Moderator

Date Joined Feb 2009
Total Posts : 7188
   Posted 7/3/2011 9:09 AM (GMT -6)   

I have had allergy-induced asthma since childhood. I have seen several asthma doctors, as well as some great ENT's. When my reflux started getting worse (at first without my knowledge), my lungs started going downhill.

The problem with your issue, is that even a small amount of reflux just occasionally can create havoc for some people.

In my case the asthma doc was very upset with GI docs who only look at how the reflux is affecting the esophagus. They don't realize that an occasional relaxation of the LES can set things in motion to create lots of issues for those of us with atypical symptoms.

Finally, after four years+ of going back to my GI doc and being told that my reflux wasn't that bad, (although it was creating horrible lungs), the GI said, "I guess if you were getting a couple good reflux episodes a day it might be enough to cause your problems".

Bottom line...you don't have to have a wide-open-all-the-time LES to cause your problems. Intermittent reflux can be enough to do harm to some of us.

Good luck finding an answer.

Regular Member

Date Joined Apr 2011
Total Posts : 76
   Posted 7/3/2011 9:13 AM (GMT -6)   
Do side-effects occur with all the brands and types of PPIs? You might want to change until the find one that doesnt give you side effects. Nexium (esomeprazole) gave me problems so know I take pantoprazole.

I personally think that the root cause of the weakening of the LES or UES is definetly related to the nerves.

I have a slight scoliosis and I think that could be the root cause of my LPRD. I have mentioned it to my doctors but they dont seem to give it any importance!

As you already know, Endostim is developing/testing a device to restore natural funcionality of the LES through neurostimulation.
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