I take enzymes to help with digestion in the small intestine, but they don't do anything for reflux. Some people might have low acid, but all these things need to be tested for by a doctor.
If you have reflux you need to find out WHY you have it. Do you have a large hiatal hernia causing your valve not to be able to close, or maybe a weak valve? There are loads of tests, some not really horrible, like the barium swallow that can show what's going on.