Phosphatidylcholine and the LES and the gall bladder - technical input required!

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mudmagnetmum
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Date Joined Apr 2011
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   Posted 7/22/2011 5:23 PM (GMT -6)   
Just extracting this from within a different thread where gall bladder and bile reflux was being discussed: -


Interesting line of enquiry....... my symptoms are worst between waking and midday, and at any time that I have to fast (e.g. for tests, not frequent I know, but I know it makes me feel terrible!).

Coffee, which so many of us can't tolerate (but if you're anything like me you'll keep trying!!), stimulates the gall bladder and the production of bile. Could that be one of the reasons it aggravates our symptoms?

I don't claim to be an expert, but I've studied nutrition (as a form of complementary medicine), so a supplement sprang to mind when I read about Keith's gallbladder/bile connections - choline, or maybe phosphatidyl choline (it is found in lecithin, and in some contexts they are talked about as the same thing). Phosphatidyl choline (PC) is needed for bile formation and I think is used in supplement form to prevent gallstones (haven't verified the science on that but it's a popular supplement for liver and gall bladder issues). Also, there's some research (heavy techi stuff - will post a bit below this) that says PC prevents inflammation/injury to the GI tract and the oesophagus. Furthermore, there seems to be some role of PC (and inositol) in closing the LES (more heavy techi stuff).

So maybe there's an underlying connection if I'm reading the blurb correctly -
Phosphatidylcholine is involved in gall bladder function, the protective mucus layer of the GI tract and in signalling the LES to close. PC is also said to help with anxiety and panic disorders.......

Probably an issue worth exploring if other folk can help wade through the info !
New stuff: GERD. Interstitial Cystitis
Lifelong stuff: Food allergies, eczema, asthma

Post Edited (mudmagnetmum) : 7/22/2011 4:43:00 PM (GMT-6)


mudmagnetmum
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Date Joined Apr 2011
Total Posts : 1604
   Posted 7/22/2011 5:24 PM (GMT -6)   
Blurb (very techi reading) relating to the above comments by myself:-
 
http://www.nature.com/gimo/contents/pt1/full/gimo24.html

"Contraction of LES cells by maximally effective dose of acetylcholine (ACh) is shown as an example of signal transduction in response to high doses of agonists."

AND
 
http://www.ncbi.nlm.nih.gov/pubmed/16550803

"The neuronal nitric oxide synthase--mast cell axis plays
an important role in the esophageal mucosal defense system. Systemic PC
pretreatment affords effective protection through ameliorating the
bile-induced ATP depletion and secondary inflammatory reaction"

This second ref opens with "Biliary regurgitation plays important role in gastro-esophageal reflux disease"

http://journals.lww.com/shockjournal/Fulltext/2008/12000/Oral_Phosphatidylcholine_Preserves_the.19.aspx?WT.mc_id=HPxADx20100319xMP
This 3rd ref talks about PC being protective. In the article it refers to "LPS" - I think it means lipopolysaccharides produced by bacteria.

If anyone is able to digest (ha ha) this stuff and comment, I would be interested to hear your thoughts!
 
Edit:  I linked your first url in this post, the second one I changed as you had copied it from another forum and I looked up the URL for the original article by Eros G, Kaszaki J, Cz√≥bel M, Boros M.  The third link I left as you had it as I ran out of steam looking the sites up.  smilewinkgrin
 
Respectfully,
Kitt

Post Edited By Moderator (stkitt) : 7/22/2011 8:21:28 PM (GMT-6)


stkitt
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Date Joined Apr 2007
Total Posts : 32602
   Posted 7/22/2011 6:00 PM (GMT -6)   

Please note multiple identical posts in the same topic forum are  not permitted. If you have a question re this rule please email me.

Kindly,

Kitt


~~Kitt~~
Moderator: Anxiety/Panic, Osteoarthritis, GERD/Heartburn and Heart/Cardiovascular Disease.
www.healingwell.com

"If you can't change the world, change your world"

mudmagnetmum
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Date Joined Apr 2011
Total Posts : 1604
   Posted 7/22/2011 6:26 PM (GMT -6)   
Was just trying to move it to a new thread :-(
New stuff: GERD. Interstitial Cystitis
Lifelong stuff: Food allergies, eczema, asthma

stkitt
Elite Member


Date Joined Apr 2007
Total Posts : 32602
   Posted 7/22/2011 9:04 PM (GMT -6)   
Would you like me to delete the other post in the old thread ?  That way it will be posted where you want it ?
 
Kindly,
Kitt
~~Kitt~~
Moderator: Anxiety/Panic, Osteoarthritis, GERD/Heartburn and Heart/Cardiovascular Disease.
www.healingwell.com

"If you can't change the world, change your world"

mock turtle
Regular Member


Date Joined Mar 2011
Total Posts : 467
   Posted 7/22/2011 9:34 PM (GMT -6)   
mudmagnetmum

Phosphatidylcholine...very interesting...thanks

mudmagnetmum
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Date Joined Apr 2011
Total Posts : 1604
   Posted 7/23/2011 1:34 AM (GMT -6)   
Yes please Kitt!

Thanks MT, something else for us to try out!

MMM
New stuff: GERD. Interstitial Cystitis
Lifelong stuff: Food allergies, eczema, asthma
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