i have read and been told that taking aspirin is associated with reflux and may, like chocolate, mint alcohol etc be one of those things that weakens the LES
check out the first 4 paragraphs of this old article about the chemoprotective aspects of aspirin versus esophageal cancer
and please read the entire article at source... just facinating
"SEATTLE, March 1 -- Aspirin and other NSAIDs decrease the risk of progression of the most aggressive form of Barrett's esophagus to esophageal cancer, researchers here reported.
The researchers also identified a high-risk cluster of four known cancer biomarkers in patients with Barrett's that significantly increased their risk of developing esophageal adenocarcinoma, according to a report in PLoS Medicine.
Barrett's patients with no genetic abnormalities upon joining the study had a 12% risk of developing esophageal cancer after 10 years, whereas those with three or more abnormalities at baseline had an almost 80% risk, said Patricia Galipeau, a research technician in the laboratory of Brian Reid, M.D., Ph.D., of the Fred Hutchinson Cancer Research Center.
Galipeau and colleagues also found that those with three or more of the biomarkers who used aspirin or other NSAIDs had a 30% risk of esophageal cancer after 10 years, while those with the same biomarkers who did not use NSAIDs had a 79% risk of developing cancer within a decade."
By Judith Groch, Senior Writer, MedPage Today
Published: March 01, 2007
Reviewed by Zalman S. Agus, MD; Emeritus Professor at the University of Pennsylvania School of Medicine .