H2s use not associated with increased risk of esophageal cancers

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

mock turtle
Regular Member

Date Joined Mar 2011
Total Posts : 467
   Posted 9/1/2011 4:28 PM (GMT -6)   
many here have read about research trying to determine if taking PPIs reduces risk of esophageal cancer

weve read some findings indicating PPI usage may be associated with increased risk but its not clear if this relationship is associational,,,or,,, is causal as some doctors propose


weve been looking for similar studies regarding H2s (famotidine, ranitidine etc)


here it is...or was, the study was done a decade ago at fred hutch in seattle

Gastroesophageal reflux disease, use of H2 receptor antagonists, and risk of esophageal and gastric cancer.
Farrow DC, Vaughan TL, Sweeney C, Gammon MD, Chow WH, Risch HA, Stanford JL, Hansten PD, Mayne ST, Schoenberg JB, Rotterdam H, Ahsan H, West AB, Dubrow R, Fraumeni JF Jr, Blot WJ.

Fred Hutchinson Cancer Research Center, and University of Washington, School of Public Health & Community Medicine, Department of Epidemiology, Seattle 98109-1024, USA. dfarrow@u.washington.edu

The incidence of esophageal adenocarcinoma has risen rapidly in the past two decades, for unknown reasons. The goal of this analysis was to determine whether gastroesophageal reflux disease (GERD) or the medications used to treat it are associated with an increased risk of esophageal or gastric cancer, using data from a large population-based case-control study.

Cases were aged 30-79 years, newly diagnosed with esophageal adenocarcinoma (n = 293), esophageal squamous cell carcinoma (n = 221), gastric cardia adenocarcinoma (n = 261), or non-cardia gastric adenocarcinoma (n = 368) in three areas with population-based tumor registries. Controls (n = 695) were chosen by random digit dialing and from Health Care Financing Administration rosters. Data were collected using an in-person structured interview.

History of gastric ulcer was associated with an increased risk of non-cardia gastric adenocarcinoma (OR 2.1, 95% CI 1.4-3.2). Risk of esophageal adenocarcinoma increased with frequency of GERD symptoms; the odds ratio in those reporting daily symptoms was 5.5 (95% CI 3.2-9.3).

**Ever having used H2 blockers was unassociated with esophageal adenocarcinoma risk** (OR 0.9, 95% CI 0.5-1.5). The odds ratio was 1.3 (95% CI 0.6-2.8) in long-term (4 or more years) users, but increased to 2.1 (95% CI 0.8-5.6) when use in the 5 years prior to the interview was disregarded. Risk was also modestly increased among users of antacids. Neither GERD symptoms nor use of H2 blockers or antacids was associated with risk of the other three tumor types. (my emphasis added)

Individuals with long-standing GERD are at increased risk of esophageal adenocarcinoma, whether or not the symptoms are treated with H2 blockers or antacids.

PMID: 10782657 [PubMed - indexed for MEDLINE]


Veteran Member

Date Joined Oct 2009
Total Posts : 739
   Posted 9/1/2011 6:05 PM (GMT -6)   
thanks for finding this info!

mock turtle
Regular Member

Date Joined Mar 2011
Total Posts : 467
   Posted 9/1/2011 10:10 PM (GMT -6)   
welcome...glad to be of service

Veteran Member

Date Joined Jun 2011
Total Posts : 795
   Posted 9/2/2011 4:28 AM (GMT -6)   
OK, prescription forms of H2 blockers include:
Tagamet (cimetidine)
• Pepcid (famotidine)
• Axid (nizatidine)
• Zantac (ranitidine)
Nonprescription (over the counter) forms:
• Tagamet-HB
• Pepcid-AC
• Axid AR
• Zantac 75

I was taking Zantac, but my GI doc said they become ineffective over time, switched me back to my current PPI, Nexium. I am extremely worried about the calcium loss and bone thinning from PPI's since I have orthopedic and neurological problems. Is he correct?

mock turtle
Regular Member

Date Joined Mar 2011
Total Posts : 467
   Posted 9/2/2011 10:19 AM (GMT -6)   
i dont know and ive tried to find the answer with lots of search terms

the body is known to build tolerance to many, if not most medications and it seems that just as with PPIs, why wouldnt the body grow a greater number of parietal cells in response to acid suppression

but bottom line is , i dont know if H2 acid reducers loose their effectiveness over time of use

btw H2s are not without risks too , as you have stated,

yes one can boost B12 and calcium and hope to compensate...known to be at least somewhat effective...but the long range multi-decade longitudinal studies arent apparently available

Veteran Member

Date Joined Jun 2011
Total Posts : 795
   Posted 9/2/2011 12:13 PM (GMT -6)   
Yeah, especially the PPI's have been around only 10 years or so I believe. The H2 blockers have been around a lot longerI think, so there should be more info, but that doesn't mean it is easy to find. I think a lot of medical info is available only through subscription services. It also can be daunting to decipher. We all have to live longer to help find out more answers.
New Topic Post Reply Printable Version
Forum Information
Currently it is Monday, September 24, 2018 6:18 AM (GMT -6)
There are a total of 3,006,005 posts in 329,292 threads.
View Active Threads

Who's Online
This forum has 161818 registered members. Please welcome our newest member, demonsss.
234 Guest(s), 2 Registered Member(s) are currently online.  Details
Deep_sleep, elvin