I've been on and off drugs a few times. I would say less pain after one week, but up to a month to get to maximum symptom control (which in my case is not 100% relief). However, I also have gastritis and I don't think the drugs do much for that; maybe for reflux without gastritis the benefits kick in quicker?
New stuff: GERD. Interstitial Cystitis
Lifelong stuff: Food allergies, eczema, asthma