Yes, I was on PPIs. I started on 20mg Prilosec, switched to 40. Then to Nexium 40mg, then to Nexium 40mg twice a day. After being hospitalized with severe asthma related to reflux/gastritis, I was switched to 40mg Protonix twice a day.
To cover me better at night, my PCP prescribed 300mg Ranitidine at bedtime in addition to the PPIs. During a several year period, I was also on Reglan to speed up stomach emptying. It really didn't do anything for me that I could see, so I gave it up.
In the beginning, my asthma was pretty well controlled using the PPIs and of course, inhaled steroids. (I have severe environmental allergies as well, and they muddy the waters.)
As time went on my GERD must have worsened, and the PPIs no longer did the trick. That's when I finally had to give in and have the Nissen surgery. I really had no choice, since my lungs were terribly sick and as my PCP said, it was a "life threatening situation.
Good luck with your issues. Just because mine progressed and got bad enough for surgery doesn't mean yours will. Just be careful and follow up, since reflux in the lungs can create permanent damage if it's bad enough.