According to my Dr., without Barrett's you don't get adenocarcinoma...

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Date Joined Oct 2009
Total Posts : 739
   Posted 1/10/2012 8:09 AM (GMT -6)   
I posted a Swedish study a few days ago which showed a correlation between heartburn symptom severity, frequency and duration and esophageal adenocarcinoma. The study found that these were more important than the esophageal mucosal state (barrett's, esophagitis, or normal) in correlation with cancer.

My dr., who I was referred to from Mayo clinic, told me that he knows the people who did the study (Lundgregen (Sp?), and that it has since been discredited. In essence, since Barrett's was only discovered in the 70's, in the 90's it was still relatively easy for endoscopists to miss. It is believed that those from this study that got cancer w/o Barrett's really did have a small area(s) of Barrett's that preceded the cancer.

In addition, the dr. said that a number of studies since have shown that barrett's is the mediator of adenocarcinoma, meaning "if you don't get Barrett's, you can't get cancer". As a side note he said a number of studies have also shown that if you don't get Barrett's within the first little while, due to a genetic marker of the disease, then you won't get it (or have like a 2% chance of getting it).

Just wanted to post this since I did post that study a few days back and it did get a bit of attention.

As another side-note, the dr. said brocolli sprouts really aren't proven to be anti-esophageal cancer. He said studies do exist where those who consume them get less cancer, but other studies exist where the same phyto-nutrients (sp?) and anti-oxidants are injected into the esophagus (drank?), and no benefit is found. He thinks it is because people who take the time to eat brocolli sprouts are also taking care of themselves in other ways, and that is why their risk is lower.

Either way I am going to eat sprouts, but just thought I'd let people know. He said there is nothing he knows of that can help prevention apart from eating very healthy and living healthy in a general sense.

Veteran Member

Date Joined Jul 2011
Total Posts : 656
   Posted 1/10/2012 9:20 AM (GMT -6)   
Hey Daniel,

All I can say about this is that I eat 5-6 servings of broccoli and cauliflower a week and it makes a huge difference in my symptoms. Of course my whole diet is better, but I've tried eating other fruits and veggies (like peas, zucchini, and squash) and nothing makes my stomach calmer than broccoli and cauliflower.

...until the gas sets in, that is. There's my TMI moment for the day :)

Veteran Member

Date Joined Oct 2009
Total Posts : 739
   Posted 1/10/2012 11:10 AM (GMT -6)   
@ Jamaica

You are talking like me now :) I am uncomfortable with it too, because like you say on an individual level you never know. Plus, who is to say I don't have Barrett's that the endoscopist missed...I just wrote this b/c I had written about the risk of cancer w/o Barrett's according to the Swedish study. I wanted to amend that with what my dr. told me about it yesterday, in case anyone took it too seriously, etc.

mock turtle
Regular Member

Date Joined Mar 2011
Total Posts : 467
   Posted 1/10/2012 11:09 PM (GMT -6)   

your comment is thoughtful and well reasoned

i can only say that if heartburn "symptom severity, frequency and duration" and risk for adenocarcinoma are not strongly related, then one must suppose that some pre existing condition like say, genetics, or diet etc are the predominant controlling conditions for esophageal cancer

with regard to broccoli sprouts...i remain convinced that sulforaphane significantly increases apoptosis of cancer cells and as well affects significantly angiogenisis...

will sprouts halt or destroy some cancers?...we dont know..maybe...maybe not...the researchers are presently struggling with that question and NO ONE knows yet the answer

best wishes
mock turtle
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