Fish Oil and Esophageal Cancer Risk

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theacidrefluxman
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Date Joined Oct 2009
Total Posts : 739
   Posted 1/24/2012 9:10 AM (GMT -6)   
Hi all. Actually ran into this without even googling barrett's or esophageal cancer, first time I find good info w/o explicitly looking for it. Since I haven't seen this mentioned like brocolli sprouts and other things I thought it was worth posting in case anyone is interested. You can google "fish oil and esophageal cancer" if you want to see a lot of pages on it. Here is an excerpt from one.

Fish oils may help prevent esophageal cancer
NORWICH, UNITED KINGDOM. Cancer of the esophagus has a poor prognosis and is increasing in frequency. Esophageal cancer is usually preceded by a condition called Barrett's esophagus (BE) in which the normal squamous (scale-like) epithelium in the lower esophagus is replaced with columnar epithelium. about 5% of patients with BE progress to esophageal cancer. BE, in turn, is linked to gastroesophageal reflux disease (GERD) with from 10-20% of GERD patients progressing to BE.

Research has shown that colon cancer is associated with an increased expression of the COX-2 enzyme in the colon and that fish oil can reduce both the COX-2 level and the risk of colon cancer. There is also evidence that the COX-2 enzyme is upregulated in Barrett's esophagus and esophageal cancer. British researchers therefore reasoned that fish oil supplementation might also be beneficial in BE and thus, indirectly, lower the risk of esophageal cancer.

Their clinical trial involved 46 patients with previously diagnosed BE. Twenty-seven of them were assigned to receive 3 EPA (eicosapentaenoic acid) capsules daily providing a total EPA intake of 1.5 grams a day with the remaining 19 patients serving as controls. Before the start of supplementation and at the end of the 6-month trial period, all participants underwent endoscopy during which appropriate biopsy samples were obtained. Analysis of the samples showed a significantly increased concentration of EPA and a significantly decreased level of COX-2 proteins in BE tissue in the supplement group, but not in the control group.

The researchers conclude that regular supplementation with relatively small doses of EPA results in significant incorporation of metabolically active long-chain amoega-3 fatty acids into BE tissue and a concomitant, beneficial decrease in COX-2.
Mehta, SP, et al. Effect of n-3 polyunsaturated fatty acids on Barrett's epithelium in the human lower esophagus. American Journal of Clinical Nutrition, Vol. 87, 2008, pp. 949-56

mudmagnetmum
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Date Joined Apr 2011
Total Posts : 1604
   Posted 1/24/2012 3:18 PM (GMT -6)   
That's a good find ARM. Thanks for posting it. Not sure how easy it is for people with GERD to tolerate fish oil - I guess some will find they can and some will find it gives them heartburn.

http://www.ingentaconnect.com/content/ben/cpd/2011/00000017/00000008/art00006
Olive oil also reduces the risk for upper digestive track cancers, as well as other cancers, so I do very much try to incorporate that into the family diet!

MMM
New stuff: GERD, Recurrent cystitis/Overactive bladder
Lifelong stuff: Food allergies/intolerance, eczema, asthma

CPA-Kim
Regular Member


Date Joined Oct 2012
Total Posts : 20
   Posted 8/8/2013 7:34 PM (GMT -6)   
Buy a high quality fish oil in capsule form and store it in the freezer. Take it either with meals or right before bed.

dencha
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Date Joined Feb 2009
Total Posts : 7181
   Posted 8/8/2013 7:46 PM (GMT -6)   
Actually, I've tasted some excellent liquid fish oil with lemon.  I thought it was going to be nasty, but not at all.
Good information, ARM!
Hope all is well...
turn  
GERD/Heartburn Moderator
Nissen Fundoplication 2/09
Allergy/Asthma

"Whatever you fight, you strengthen, and what you resist, persists.”

“Worry pretends to be necessary but serves no useful purpose”

“Accept - then act. Whatever the present moment contains, accept it as if you had chosen it. Always work with it, not against it.”
Eckhart Tolle

phil-uk
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Date Joined Jul 2012
Total Posts : 190
   Posted 8/9/2013 1:11 PM (GMT -6)   
More on fish oil and the inhibition of the growth of pre-malignant and malignant cells...

Fatty Acids Could Aid Cancer Prevention and Treatment

Aug. 1, 2013 — Omega-3 fatty acids, contained in oily fish such as salmon and trout, selectively inhibit growth and induce cell death in early and late-stage oral and skin cancers, according to new research from scientists at Queen Mary, University of London.

http://www.sciencedaily.com/releases/2013/08/130801095513.htm

mudmagnetmum
Veteran Member


Date Joined Apr 2011
Total Posts : 1604
   Posted 8/9/2013 3:36 PM (GMT -6)   
Hmmm. How does anyone swallow fish oil without having WORSE reflux?! Drat - should have taken some during my manometry - I'd have belched and refluxed pretty good on that!

MMM
GERD (3 years and counting)
Lifelong stuff: Food allergies/intolerance, eczema, asthma

phil-uk
Regular Member


Date Joined Jul 2012
Total Posts : 190
   Posted 8/10/2013 1:57 PM (GMT -6)   
Hi mum,

I don't have a problem taking my twice daily fish oil tabs. I take these with my 1x20mg Omeprazole and 1x400mg turmeric. I then eat either breakfast, or dinner as appropriate for the time of day.

Mornings I also take a Vit B tab and a very small amount [approx. 2ml] of Lactulose, for prebiotic and colon acidifying effect [combats bad bacteria and increases uptake of minerals].

This regime currently suits me very well. Not to say I don't have bad days though.

All the best

Phil

ChattDana
New Member


Date Joined Jul 2013
Total Posts : 12
   Posted 8/11/2013 9:30 AM (GMT -6)   
My homeopath has me on 4 capsules of salmon oil a day (to rebuild the myelin sheath on my nerves, since they have been ravaged by years of anxiety). I almost had to quit taking them because they were causing me to reflux. But, he told me to take them right before bed (I sleep with a wedge pillow and two pillows on top of that) and not to keep getting up but stay in bed, I guess to not stir up my stomach? And it has worked. I take the salmon oil with no problems now.

mudmagnetmum
Veteran Member


Date Joined Apr 2011
Total Posts : 1604
   Posted 8/11/2013 3:39 PM (GMT -6)   
I take linseed capsules, which you can make the same series of prostaglandins from - fish oil is a short cut, starting further down the chain. I don't have a problem taking linseed but fish oil gives me terrible reflux, and all vitamins give me pain. I find it very frustrating that I can't get into my body things that I know would help!

I can't eat salmon either - serious heartburn!

MMM
GERD (3 years and counting)
Lifelong stuff: Food allergies/intolerance, eczema, asthma
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