Anyone experience with Lyrica for Hypersensitivity?

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New Member

Date Joined Oct 2011
Total Posts : 7
   Posted 1/31/2012 5:37 PM (GMT -6)   
I had a Nissen 5 months ago and am still dealing with hypersensitivity issues to'normal' amounts of acid right below the wrap. The surgery recovery has progressed fine and I can eat just about everything now, but I am one of those people who fell into the category of hypersensitivity. So, I am trying out Lyrica and we are still working on the right dosage,but just wondering if anyone has similar symptoms to me and what they have done.


Regular Member

Date Joined Apr 2011
Total Posts : 377
   Posted 1/31/2012 7:05 PM (GMT -6)   
Hi Mamakay - you mean the pH tests showed normal amounts of acid and yet you were symptomatic before you got Nissen?

I've tried gabapentin (neurontin) - which is similar to Lyrica. It did help some - but I got side effects on it. My pH tests do show acid though and it isn't concluded if I am hypersensitive or not. They tried it since I got side effects on the PPIs/H2s. It turns out, I get side effects on most meds! Lucky me!

Regular Member

Date Joined Nov 2011
Total Posts : 417
   Posted 1/31/2012 7:07 PM (GMT -6)   
I recently had a doctor prescribe nortriptyline as an experiment to see if my LPR symptoms could be reduced by decreasing the sensitivity of the upper GI nerves. I also have "normal" reflux following a TIF in August of '11. I made it two days at 10mg per dose, but had to stop because of dizziness and impairment.


Veteran Member

Date Joined Oct 2009
Total Posts : 739
   Posted 1/31/2012 8:56 PM (GMT -6)   
I am also taking for hypersensitivity. Can I ask how you were diagnosed with this? A ph test with normal reflux, and strong symptom correlation? Also, can I ask what your symtpom is? Is it not so much burning as a discomfort/numbness?

I tried desipramine and am currently trying cymbalta. I had no change on desipramine, we'll see w/ cymbalta.

New Member

Date Joined Oct 2011
Total Posts : 7
   Posted 1/31/2012 11:37 PM (GMT -6)   
So it seems I am not alone.

My reflux was symptomatic with pain (my ph tests did show acid and motility was impaired) and acid reflux burning up my esophagus. My LES was definitely not working right and had a hiatal hernia that made it worse...had some improvement on PPIs, but acid breakthroughs constantly and especially when leaning over, lying down had more pain. So, I went the route of the Nissen, no regrets there, but I am still having pain due to hypersensitivity to acid levels. I had extreme burning pain for a while, and tried desipramine, and nortriptyline but both had side effects I couldn't handle. I tried Neurontin before the Nissen to no avail, so now I am trying Lyrica. Have seen some improvement, but we started at very low dose and moving up. The side effects are tolerable and just hoping that his drug will help me get out of the cycle of pain. My pain is less burning now and more like constant discomfort/ache that won't go away. Still try to watch my diet, but at least I have been able to eat more normally than before. I had lost 25 lbs because I was struggling so much with the reflux pain.

Forum Moderator

Date Joined Dec 2008
Total Posts : 4961
   Posted 2/1/2012 2:13 AM (GMT -6)   

Not sure if this is what is going on, but some people have food hang up at the wrap and this will ferment causing pain. I believe Denise has this issue.
Also depending how much damage was done before surgery it may take ay where from 6 months to a year or so the fully heal. Then there is hypersensitivity because the esophagus is a "dumb" organ and gain perceive "normal" or small amounts of reflux as a full out acid onslaught.

Have you tried carafae? It coats the lining if the esophagus and stomach. It comes in a suspension and pill form. The suspension works the best, but is expensive. The pills are relatively cheap and can be mixed with water to make a suspension to drink.

Take care,
Moderator: GERD/Heartburn
Nissen 6/06 and 5/09
#3 on 8/24/11
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