I am currently trying to figure out what is causing my chest pains as well. I have been suffering from them for about a year now. I am currently seeing my second GI doc, since the first didn't help me much. I saw him today in fact. He initially put me on 2 nexium a day, and moved me up to 3 a day, today. He was hoping the 2 a day would help with the pain, if in fact the pain is being caused by acid. My next step is to do the acid probe test, to find out how much acid if any is in my eosphagus. Once that is determined, then I think we will know a little more of what is going on. The chest pain is pretty much constant with me, daily, some days worse, some days not so bad, but always there. I have also been reading up on some other symptoms I have that fit with my GERD. I also have Barrets. I would suggest an upper GI once the heart and lungs, and possibly the gall bladder have all been ruled out. Might give you a little more insight to what you have going on. But my GI doc did say one thing today, only 4 things can cause chest pains, heart, lungs, GI, and lower back issues. So rule them out one at a time.