This may not work for everyone, but I have found aciphex is more effective for me if I take it at the end of my first meal. i believe that is the opposite of what most people are told. I must also tell you that around the time I started taking aciphex after the first meal I also started drinking spring water instead of tap water. It's always best to make one change at a time so you know, but I'm going to continue doing both since I seem to be having fewer "bad" days. I do find that keeping a record of what and when you eat and how and when medication is taken is also helpful.