I was told to wait 8 weeks for untoasted bread, but if you toast it well, you shouldn't have any problem.
I still have difficulty with large pills, and avoid them. I look for small pill substitutes...either lower dose or another type of medication-for example...Allegra is a large antihistimine, Xyzal is a tiny one. Recently I took an antibiotic, and opened the capsules and mixed them with yogurt. I take liquid calcium...etc, etc, etc.
If your wrap is tight you may always have trouble with large pills. I certainly do.