I have been on Dexilent for 6 weeks with little to no relief of symptoms (still have lump in throat when i swallow and sometimes i get mucus and throat clearing)
But I've heard varied reports on how long it takes for PPI's to work, and each one may be different. Some people say a week or two for symptoms to improve, others have told me it takes several weeks to months.
My feeling is that it depends on what your symptoms are. For those who suffer daily discomfort due to heartburn from the reflux, they may start noticing an improvement or reduction in symptoms quite fast. But for those who have more 'silent' reflux or LPR symptoms (such as myself), it may take several months for the esophagus or throat to heal once the reflux has been stopped.
When I started Dexliant, the first two weeks were twice a day (morning and night) at 60mg each. The pharmacist deemed this as the 'loading' dose. Then in the 3rd week, I'm down to just one pill at night before bedtime at 60mg. With Dexilant, you can take it on an empty or full stomach.
Since I have not seen a real improvement after 6 weeks, I am beginning to doubt if I am truly suffering from classic GERD, and it might be something else. Time and more tests will hopefully give me some more ideas with my ENT, since right now it seems it isn't working fully.