I have been on protonix for more then 3 years, and I got off it back in march. I find myself now eating a lot less my appetite is pretty bad and I have lost a good 15 pounds. Granted I have been having trouble with my nissen wrap and the remergence of heartburn which has been pretty diffficult to deal with. However, now im starting to fear something like gastroparesis since I seem to keep gradually loosing weight. I don't throw up at all, but lots of weight loss. I remember the protonix did make me hungry when I took it, could getting off a PPI cause these kind of effects?