I have been on ppi's for most of the last 12-13 years-most recently Nexium 40 mg, but have been on as high as 80 mg in the past. I had never been able to go off of them until recently without becoming very ill. about a month ago, I replaced the Nexium with Pepcid, 150 mg, which I take twice daily. I supplement this throughout the day with Tums. I have modified my diet somewhat, am eating smaller meals, and have started sleeping on a wedge pillow, which helps tremendously. I have also started drinking Aloe Vera jucice. Overall, I think I am doing pretty well, and feel better than when I was on Nexium. I I have not had very much actual reflux at all. I do still have some problems with heartburn, especially when I bend over. My abdomen is absolutely huge, which I have read can be just another side effect of the nexium, and this puts pressure on my hiatal hernia. The main problem that I have noted is that my digestive system seems "sluggish"-that is, whenever I eat something, I feel as if it sits in my stomach for a long period of time before it digests. I am also having problems with being constipated. I feel as if I never totally empty out.