When to take PPI

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Veteran Member

Date Joined Oct 2009
Total Posts : 739
   Posted 9/15/2012 9:16 AM (GMT -6)   
Its tough to time a PPI 30-60 minutes before breakfast every single day because sometimes I wake up hungry. Is it not as effective if I take it 2-3 hours before breakfast (for times I wake up earlier and go back to sleep)? Should I always strive for the 30-60 minute range, or does it not really matter as long as it is taken at least 30 (but sometimes up to 180) minutes before breakfast?


Regular Member

Date Joined May 2012
Total Posts : 121
   Posted 9/15/2012 10:45 AM (GMT -6)   
I get the best effect if I take 30 - 60 mins before breakfast. If I eat too early then I am usually sick straight after breakfast, and if I eat too much later it does not seem to be as effective. If I take and do not eat then by mid afternoon I am needing another dose. I was recently speaking with someone who was taking 3 x 30mg doses per day but was taking one straight before eating, one at lunch and one right before bed, even then he was saying that often it does not work. I explained the timing issue and he is trying to follow the 30 min rule. I have to sometimes ask what doctors are thinking when they just prescribe a higher dose without explaining the best method of administration.

Veteran Member

Date Joined Mar 2012
Total Posts : 1110
   Posted 9/17/2012 12:54 PM (GMT -6)   
I take mine about an hour before eating. I usually set my alarm an hour before I am going to get up, take the pill, go back to sleep for an hour and then eat. Or, I take my pill when I get up and get ready for work and eat on the way to work (Not the best idea but it sometimes has to be)
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Regular Member

Date Joined Apr 2012
Total Posts : 132
   Posted 9/17/2012 2:36 PM (GMT -6)   
I'm currently taking Dexilant, and I actually take it immediately before I eat my breakfast. It can be taken with or without food, and my doctor said it would be ok to take it as I get ready to eat in the morning. My last endoscopy showed that my esophagitis has healed, so it must be working.
Before Dexilant I was on Nexium and omeprazole. Those I was told to take 60 minutes before eating.

Elite Member

Date Joined Apr 2007
Total Posts : 32602
   Posted 9/17/2012 2:49 PM (GMT -6)   
To the best of my knowledge, the PPIs  need to be taken 30-60 minutes prior to eating a meal, preferably breakfast. And the eating needs to happen--if you don't eat 30 - 60 minutes afterwards, the efficacy of the drug will be reduced.
I take mine 30 minutes before breakfast everyday.  I don't eat a huge breakfast but I have made this routine for me.
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Veteran Member

Date Joined Oct 2009
Total Posts : 739
   Posted 9/17/2012 5:24 PM (GMT -6)   
Thanks everybody.

Thanks Kitt. That is what I thought, but I didn't know I had to eat at the 60 minute mark tops. I'll definitely become more disciplined in this.

New Member

Date Joined Sep 2012
Total Posts : 10
   Posted 9/18/2012 6:09 PM (GMT -6)   
My GI doctor says 1 hour is good. It is hard to wake up take your pill and wait an hour to eat. I read a study recently that the average PPI takes 1.6 hours to reach maximum blood level. Whatever 1.6 hours turns out to be, lol.

Veteran Member

Date Joined Apr 2011
Total Posts : 1604
   Posted 9/19/2012 4:33 PM (GMT -6)   

This study discusses the timing of the dose and supports the above comments.

For me, my symptoms only improved when I learnt to take it at night. Taking it in the morning gives me no protection from morning nausea and I always felt it useless to take it AFTER the nighttime reflux had already happened!! However, the evidence is good for taking it in the morning - despite the fact it doesn't work for me!

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