I'm currently taking Dexilant, and I actually take it immediately before I eat my breakfast. It can be taken with or without food, and my doctor said it would be ok to take it as I get ready to eat in the morning. My last endoscopy showed that my esophagitis has healed, so it must be working.
Before Dexilant I was on Nexium and omeprazole. Those I was told to take 60 minutes before eating.