If I understand your question correctly, you are referring to GERD medications and procedures:
0. Natural ways: diet change, bed inclination/elevation etc.
1. H2 blockers (zantac, pepcid, tagament etc.)
2. PPIs (prilosec, nexium, prevacid, protonix, aciphex zegrid etc.)
3. Fundoplications (Full, Partial, TIF)
Depending on the severity and the nature of the condition, most GERD patients (I don't have the exact numbers but my guess is 90%) can control and manage their symptoms with either 0, or 1 or 2 (or a combination of these 3). Some patients end up going under the knife (3 or 4). Most of them get well after these procedures but few of them may have to live with side effects as a result of 3 or 4. Then, there are some of the unfortunate few for whom none of the above works and they try to live with the symptoms.