Is Dexilant (Dexlansoprazole) losing it's effectiveness?

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Gastricman
Regular Member


Date Joined Jan 2013
Total Posts : 294
   Posted 1/18/2013 4:28 PM (GMT -6)   
To all who take it,
 
I have been using Dexilant @ 60mg QD (once daily) for my severe GERD symtoms for about 5 months now.
I'm beginning to feel a lack of coverage about 15 hours post dosing and I wonder if it is losing it's effectiveness or my GERD is just getting a bit worse.
 
I understand that this is the PPI drug of last resort before surgical intervention.
 
Does anyone else have a similar problem?
 
Cheers!
 
GM :-)

Post Edited (Gastricman) : 1/18/2013 3:31:16 PM (GMT-7)


shrtcak81
Regular Member


Date Joined Jan 2013
Total Posts : 165
   Posted 1/18/2013 5:29 PM (GMT -6)   
Hi Gastricman,
It could be. I have been through all the PPIs. Used to be on Nexium and Prilosec for 4 years each before they lost effectiveness. Then about 5 years ago, all PPIs started to not be effective for me. The one that was the best was Prevacid and was on that until a few months ago when I really started having worse symptoms. I am now on Aciphex and it's working about the same as Prevacid was a while back. Still have burning in my throat almost constantly. Don't know what's going on but I'm going to get some tests done soon to figure it out and possibly get surgery. I'm leaning towards the Linx and have been following NDL's recovery process. But yes, the PPIs do lose effectiveness over time, could be months or years. Dexilant hardly helped me at all :(

- Crystal

Gastricman
Regular Member


Date Joined Jan 2013
Total Posts : 294
   Posted 1/19/2013 12:06 PM (GMT -6)   
Hi Crystal,
 
Thanks for your reply.
 
I can tell you form personal experience that all these PPI's have adversely affected my Bone Density, verfied by several DEXA scans, causing Osteopenia. The have left me open to several gastrointestional infections (probably due to my higher stomach Ph) at the point where the mere mention of a restaurant makes me break out in sweats. So I need to eat home or from limited hygienic sources - but what kind of life is this?
 
Eating out right now is like playing Russian Roulette ;) Am I the only one?
 
PPI's also lowered my serum Ferritin level into the teens, FWIW.
 
Now I am faced with either a Nissen Total Wrap (360) or the LINX procedure and get off these PPI's.
 
Hard choices ahead.
 
Best,
 
Gastricman :-)

Post Edited (Gastricman) : 1/19/2013 11:09:37 AM (GMT-7)


Gastricman
Regular Member


Date Joined Jan 2013
Total Posts : 294
   Posted 1/21/2013 8:54 AM (GMT -6)   
Hi.
 
I have been noticing that when I wake up in the AM the back of my throat is irritated, which shows me that the coverage of the Dexilant (as above) is not providing 24/7 relief. The way I currently dose the Dexilant is to take it 1/2 hour before dinner - (as to improve the nighttime coverage) as a matter of fact the product brouchure says that it may be taken without regards to meals.
 
Any suggestions?
 
Thanks,
 
Gastricman :-)

Post Edited (Gastricman) : 1/21/2013 7:58:58 AM (GMT-7)


shrtcak81
Regular Member


Date Joined Jan 2013
Total Posts : 165
   Posted 1/21/2013 9:06 PM (GMT -6)   
Looks like we're in the same boat:( I haven't had any gastrointestinal infections, but in order to eat a bland diet, I need to eat at home too. I tried the paleo diet for only 5 days because it was so difficult and I didn't feel any better, but I probably didn't give it enough time. Lately I've been eating pretty bad because I figure that no matter what I eat, I have symptoms, so what the heck. Might as well try to enjoy food anyway. But I do avoid all spicy and citrus foods. I've only been indulging in too much sugar lately, mainly chocolate here and there. I know it's bad, but I suffer anyways.

How long have you been on PPIs? I'm only 31 and i'm afraid that my bone density is suffering. I need to get off these things! But the only way for that to happen is surgery:( Yes, hard choices ahead for sure!

I'm not sure about the Dexilant. I've always taken them a 1/2 hour before meals. Dexilant didn't work good at all for me. I'm on Aciphex twice a day right now and of course, still burning. I have burning in the morning as well before I've eaten anything. Also, I have a bitter/sweet/sour taste on my tongue most of the time. How about you?

shrtcak81
Regular Member


Date Joined Jan 2013
Total Posts : 165
   Posted 1/21/2013 9:07 PM (GMT -6)   
I do have gastritis that comes and goes, and I first got it while on PPIs, go figure! Makes me think if the PPIs are messing my stomach up and actually gave the gastritis to me...

Gastricman
Regular Member


Date Joined Jan 2013
Total Posts : 294
   Posted 1/22/2013 7:04 AM (GMT -6)   
Hi Crystal,
 
PPI's are a blessing and a curse.
 
Only recently have the side effects been proven by science, such as decrease in bone density, being susceptible to frequent gastointestinal infections, etc. I'm 48 and have been on PPI's since I was 35 - this is not a misprint. GERD is progessive which means that it doesn't get better, only worse with the only high degree of "cure" being surgery.
 
I was on Protonix 40mg/BID (total 80mg/day) with relatively good control up to a year ago, before I started to get sick eating out at restaurants. Severe vomiting, cramps, diarrhea - you name it. So, I eat at home where everything is controlled and no problems. Since my GERD became worse I was tranferred to Dexilant (as above) and am now getting a burning in the back of my throat suggesting thet the coverage (at maximum dose ) is waning.
 
It would not surprise me if the Protonix did other things to my gut, above and beyond when I had described above. I have always had a sensitive GI tract and feel a twinge of discomfort in the stomach/intestinal area.
No problems with taste or tongue, but I always avoid acidic foods since I am so senstive to the taste of them.
 
My only chance left is to bide some more time and opt for surgery, either the LINX of a total 360 Nissen.
 
Gastricman :-)
 
 
 
 

Gastricman
Regular Member


Date Joined Jan 2013
Total Posts : 294
   Posted 1/22/2013 1:35 PM (GMT -6)   
Hmm...
 
Think I am in for some problems. redface
 
The Dexilant, as per my previous posts in this threat is not totally keeping my reflux in check.
 
I bent over this AM to pick up some light tools in my basement and I had a rush of reflux straight up to the back of my throat. Besides calling my Gastroenterologist, are there any ideas from the audience that my be of help?
 
Again, am I the only one experiencing this, even on another PPI?
 
Thanks,
 
Gastricman smhair

shrtcak81
Regular Member


Date Joined Jan 2013
Total Posts : 165
   Posted 1/23/2013 9:58 PM (GMT -6)   
There has got to be other people in the same boat! Yes, it seems like you're right there with me, not getting full coverage on a PPI. You've been on them as long as me, it's been 13 years! I did not know until fairly recently that I should not be on PPIs long term! I even got gastritis while being on them...what does that mean?!? It means that something is up with these drugs. Out digestion is impaired. It's not right at all. I'm definitely opting for surgery assuming that I'm a candidate because this is taking over my life and I can't live like this anymore. Constant burning in my throat! Same thing for you too? I don't know what to do:( Gaviscon helps somewhat, but usually nothing really takes it away, only the edge of off of it. I eat tums all day. Chewing gum does seems to help distract me from it. I'm at a loss too Gastricman:(

Gastricman
Regular Member


Date Joined Jan 2013
Total Posts : 294
   Posted 1/24/2013 8:53 AM (GMT -6)   
Hi Crystal,
 
I have been on a myriad of PPI's over the years.
Currently on 60mg/day of Dexilant, and Protonix 80mg/day before that.
 
For the past few months on the Dexilant, I have been feeling fairly well. However, I am starting to have some weird GI symptoms, exactly the same as when I was on the Protonix. It is a dull, nauseous ache from the pit of my stomach going down into the intestines. I had many tests, Blood, Stool, MRI, CAT, Upper and Lower endoscopies and finally a Hydrogen Breath Test to detect bacteria in the Small Intestine.
 
With the exception of the Hydrogen Breath Test, all others were generally normal (of course, the upper endoscopy showed GERD and a bit of patchy inflammation in the stomach.) I was given a very potent and expensive (!!) antibotic for the Small Intestine which didn't do anything for me. My doctor is mystified.
 
However, I am beginning to think that as the PPI loses it's control of the reflux, something might be happening in my gut to make me feel lousy, aside from the reflux part. All I want to do is lie in bed, even though I push myself not to do so. The feeling is like being gently "kicked" in the adbominal area and I feel (by touch) that my Stomach and Intestinal areas are a bit sensitive.
 
Please let me know if you share these experiences and for all others, please feel free to chime in!
 
Thanks,
 
Gastricman :-)

Post Edited (Gastricman) : 1/24/2013 10:35:00 AM (GMT-7)


Lallabee
Regular Member


Date Joined Dec 2012
Total Posts : 20
   Posted 1/27/2013 3:49 PM (GMT -6)   
Gastricman, thank's for sending me to your link. I'm in the same boat. I didn't know that Dexilant was the last resort medicine.
It worked well for me for the most part, but there were times when I'd wake up in the morning and feel like everything I'd eaten the night before was just sitting in my stomach and all the way up to my throat.
After all, how do our bodies even digest the food we eat with all these meds that neutralize the acid? We have acid in our gut for a reason. I think starting on any PPI was a bad idea for me. I've been on them around 13 plus years.
I tried to go off PPI's last summer through a Naturopathic Doc, and had total rebound acid.
It was miserable. I'm sure all the acid that came back did even more damage than I already had. My throat was literally burnt from the acid.
I am off the Dexilant for now due to financial reasons. Even with a discount coupon and my health insurance, the cost is too much. I'm taking 40 mg of Prilosec, and sometimes an extra dose at night, and with that, woke up with heartburn.

Even though I'm scared of having the Nissen, I've resolved that it's the right thing to do. It's not natural to have to take a pill just to fuel your body.

Gastricman
Regular Member


Date Joined Jan 2013
Total Posts : 294
   Posted 1/27/2013 6:30 PM (GMT -6)   
Hi Lallabee,

Call Takeda Paramceuticals, the manufacturer of Dexilant and speak to a human in their patient services devision at their corporate number. Your MD can also order free samples in small bottles of 5 each, both 30mg and 60mg. Prilosec is OTC now, since it has been out for so long and the efficacy is nowehere near the Delixlant as a bridge to surgery. Besides the Nissen (and which variant it is) there is also the LINX surgery.

Hope this helps.

Gastricman :-)
New Topic Post Reply Printable Version
Forum Information
Currently it is Saturday, June 23, 2018 6:39 AM (GMT -6)
There are a total of 2,974,460 posts in 326,177 threads.
View Active Threads


Who's Online
This forum has 161278 registered members. Please welcome our newest member, centerfield.
306 Guest(s), 1 Registered Member(s) are currently online.  Details
RobLee