I don't think I mentioned it before, but for about
the past 4 days I've been taking alpha lipoic acid, which has some evidence for helping with burning mouth syndrome and neuropathic pain. However it also commonly causes heartburn/GI symptoms in people who don't have them to begin with. For the first few days I was OK, but Saturday I began to feel chills, which have always seemed to start in my stomach. I've always thought it was a sign of gastritis. The only other thing that may be causing stomach irritation is the aspirin or naproxen that I've been taking as part of the anti allergy/inflammation cocktail. But it is said that taking an acid blocker (part of the cocktail) helps to counteract stomach upset.
I've also taken R-lipoic acid which some people say has fewer GI effects, I only took it 2 days so far, but still getting some chills. Given the fact that ALA is known to cause GI problems, I'm going to stop that, continue with the aspirin-based allergy cocktail, and hopefully the chills will go away.
On the allergy cocktail; as I mentioned it has been the best thing I've tried so far, but it only decreases my symptoms so much. In the original paper, all the patients were described as starting out with constant 10/10 burning pain (which sounds MUCH worse than what I have), and in 2 of the 3 cases, their pain went to level 0 or level 1. My symptoms are, at worst 6/10, and they've improved to maybe 3.5/10. So while this cocktail is helping some, I do not believe I have the same condition as the people who were so helped by it.
I was flipping through Maxim magazine yesterday when I saw an ad for a workout supplement, something like "dopamite". I was thinking it was strange that a product might affect dopamine since I thought anything like that would be prescript
ion. The reason that I am interested in dopamine is because there are papers suggesting that dopamine can play a role in burning mouth syndrome (BMS) and that people who hadn't responded to traditional treatments, had responded to pramipexole. I'd sent that reference to my PCP, but she opted to send me to neurology rather than prescribe that for me. Pramipexole is a dopamine receptor agonist, essentially it acts as a substitute for dopamine by triggering the same receptors. In my trials of various drugs, none of them have been dopamine agonists. In fact, olanzapine (Zyprexa) is an dopamine antagonist, just the opposite.
Anyway, I headed over to amazon (where I get all these supplements I've tried) and just for kicks, typed in "dopamine". I was surprised at all the results available, I really thought I had searched for natural dopamine supplements before but I guess I hadn't. Long story short, I ended up ordering a supplement called 'NOW Foods DOPA mucuna'. It is made with velvet bean which contains L-DOPA, and it is converted to dopamine. Like pramipexole, it is used in the treatment of Parkinsons.
So, I was very glad to be able to try something with my dopamine system without having to wait 2 months to see the neurologist. It will be here Tuesday and I'll start then and report back any improvements.
Good link on velvet bean/l-dopa..www.rain-tree.com/velvetbean.htm#.UZlbMMplEXY
One other note while I'm here. Back before ever taking a PPI, having the tight throat, the only other time when my throat wasn't bothering me as much was when I had a headache. Or when I had tongue burning. I'll try to encapsulate all this for the neurologist, and hope they can make some sense of it, but honestly I doubt they will.
Post Edited (drtinsac) : 5/19/2013 5:36:03 PM (GMT-6)