Long Term PPI Use linked to Gastroparesis

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Regular Member

Date Joined Jan 2012
Total Posts : 87
   Posted 3/31/2013 8:35 PM (GMT -6)   
Have any of you that have been on PPIs long term gotten Gastroparesis as a result? I've read online that this is possible, and I'm wondering if any of you have experienced it?

I'm a bit frightened because i have been on a high dose of Nexium for 1.5 years now (80mg / day) and I'm starting to feel like I have some motility issues. It feels like a brick is sitting in my stomach often times after I eat.

If it is possible that they cause gastroparesis, would going off of them "cure you" of this? Or is your stomach permanently messed up from taking PPI's too long.

Here's one doctor listing all the potential side effects (frightening stuff):

Any feedback appreciated. Thanks!

Roger D.
Regular Member

Date Joined Jul 2011
Total Posts : 41
   Posted 4/1/2013 9:19 AM (GMT -6)   
I went off my PPIs following my Fundoplication surgery 18 months ago. I had been on double dose of PPIs for 2 years. 3 months after the surgery I had the feeling of "a brick is in my stomach after eating". I was prescribed Domperidone which helps. I don't know if this is from the PPIs; a side effect of the surgery or something else.

Post Edited (Roger D.) : 4/2/2013 6:45:31 AM (GMT-6)

Regular Member

Date Joined Mar 2008
Total Posts : 149
   Posted 4/1/2013 9:32 AM (GMT -6)   
I guess I'm screwed. I've been on Nexium 40mg daily for 13 years. However I don't feel any symptoms or side effects. Maybe the only side effect I am experiencing is Vitamin B12 and B6 defincency.

New Member

Date Joined Apr 2013
Total Posts : 3
   Posted 4/2/2013 1:45 AM (GMT -6)   
I'm new to this site and this is my first post. I have been taking Nexium for about 7 years at 20mg a day. I don't feel any side affects but I would like to get off it. I'm looking at this site trying to gather information to make lifestyle changes. After reading many post I'm motivated to try a lot of different ways to improve my condition.
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