Delayed rebound?

New Topic Post Reply Printable Version
48 posts in this thread.
Viewing Page :
 1  2 
[ << Previous Thread | Next Thread >> ]

DOGGBONES
Veteran Member


Date Joined Apr 2012
Total Posts : 707
   Posted 4/11/2013 11:38 AM (GMT -6)   
I stopped taking my ppi on 3/19/13 (cold turkey), as it seemed to cause as many issues as it was resolving. For the first 3/4 days I had some minor rebound but my globus had improved. The next 7/8 days I felt improved (not cured) of all symptoms, then almost 2 wks into no ppi's hear came the burn and globus returned.
 
Is it possible for this to be some sort of delayed rebound? I was taking dexilant (it's delayed release), how long of a "half life" could it have? Is it really possible to get rebound 2wks after stopping ppi?

inpinkagony
Regular Member


Date Joined Mar 2013
Total Posts : 274
   Posted 4/11/2013 12:16 PM (GMT -6)   
Dogg me and you are very smilar I started getting the globua feeling after getting of the pills or more like during the pills, I am starting to wonder if I have lpr or is it anixety another case of my symptoms are sinus infection, smelly mucus in my mouth on and of during odd times of the week and sour taste all day, but the globus is at it's worst in the morning ! I am really scared because I already have gerd and having lpr is so much more worse I am going to see an ent and I hope to hear some good news but it i have lpr I do not what to do because this instantly kills really quickly since the throat is 100 x more sensitive and for the rebound its gonna take u a long time because the longer u been on it the longer it's gonna take to completely subside

inpinkagony
Regular Member


Date Joined Mar 2013
Total Posts : 274
   Posted 4/11/2013 12:17 PM (GMT -6)   
Did u have globus before Or after The ppi?

ericapeace2000
Forum Moderator


Date Joined Mar 2012
Total Posts : 1110
   Posted 4/11/2013 12:52 PM (GMT -6)   
I tried this last year. Around day 5, I was in terrible pain. I went on half the dose of the PPI I was on and then my GI put me on Zegrid which did not work for me. I soon after surrendered and went back on a full dose. I want to get off but I am too afraid. When all this started I had a knawing stomach pain, I did not have all these symptoms. I don't know if it got worse or the medication made them appear. Sigh.
GERD Moderator; Diagnosed GERD, no other medical conditions (this one is enough) ; Gluten free since 2012; low dairy since 2012

Pat Tall
Veteran Member


Date Joined Aug 2012
Total Posts : 950
   Posted 4/11/2013 2:17 PM (GMT -6)   
Half life of Dexilant is approximately two hours for healthy individuals. A little longer for older individuals.

DOGGBONES
Veteran Member


Date Joined Apr 2012
Total Posts : 707
   Posted 4/12/2013 5:37 AM (GMT -6)   
ercia,
It just seemed like the right time to part ways with my ppi. My intent was to tapper down but I ended up going cold turkey, not sure what I was thinking but I'd rather not turn back now. I need to ride this out for a couple months, so my body can reset itself and I can give it the "all natural" approach before I even consider surgery. I'll give the magnesium a try to rid me of this lump in the throat issue. I can hear my wife already "what kind of snake oil did you buy now"? Can't say I blame her, I have a huge collection of supplements.
 
inpinkagony,
I have suffered from gerd for several years, I never had lpr symptoms (lump in the throat) until I took ppis daily. Now off of ppis I still struggle with the lump. Also, I never had water brash or sour taste until daily ppi use, that has improved (not fully gone) now that I'm off the ppi.
 
Pat Fill,
Maybe 'half life" was the wrong term? What I meant was, How long can it take before all traces of the ppi have been removed from the body? I would assume it could take several days or even a couple weeks, as in my case (I believe).

sunbeam48
Veteran Member


Date Joined Jun 2011
Total Posts : 795
   Posted 4/12/2013 9:05 AM (GMT -6)   
Doggbones, I believe you can experience rebound for up to 8 weeks after you d/c your ppi. There was a study that demonstrated this. That doesn't mean there is any residual ppi in your body. Your body is overcompensating for having the acid cut back.

DOGGBONES
Veteran Member


Date Joined Apr 2012
Total Posts : 707
   Posted 4/12/2013 9:12 AM (GMT -6)   
sunbeam,
Thanks for the info., I'm working on my fast track diet. Still trying to perfect it but it's going to take some time. Ooohhhh the rebound.

inpinkagony
Regular Member


Date Joined Mar 2013
Total Posts : 274
   Posted 4/12/2013 9:15 AM (GMT -6)   
DOGG: exactly what happened to me, I started experiencing the sour taste and the globules after I got off the ppi, its so weird, maybe it could be vitamin deficiency or anxiety because if you go online all those are possible side effects I read from this chart that shows longer term of PPI use, also everyone reacts different to drugs so that could be another possibility.well i am going to the ent today and I hope to hear some good news, I am thinking about getting a larnoscopy done, just to rule out LPR which I am nervous about but I will let you know how it goes I hope we both have answer soon. you know another thing I got from getting off the pills is burning stomach which gradually went down over the months but sometimes I get it sometimes I don't

dogg bones you should taper down from the pills but then again maybe you can h2 blockers can do something else but I do believe for you the rebound will take a while trust me it can take up to 26 weeks sometimes depending how long you been on the pills.

Snowinsummer
Regular Member


Date Joined Jan 2013
Total Posts : 40
   Posted 4/12/2013 10:42 AM (GMT -6)   
I also had a major flare up about two weeks after discontinuing medication.... Had to take zantac for a couple days. I attributed it to me going too fast at adding certain foods/drinks back into my diet. Maybe it was just rebound after all.

DOGGBONES
Veteran Member


Date Joined Apr 2012
Total Posts : 707
   Posted 4/12/2013 11:07 AM (GMT -6)   
I have been trying to control symptoms with diet, carafate, zantac, tums, and supplements (dgl, d3 and will add mag).
 
snow, your delay in rebound sounds just like mine....interesting.
 
pink, good luck at your app. today.

DontStealMyBacon
Regular Member


Date Joined Jan 2013
Total Posts : 186
   Posted 4/12/2013 2:58 PM (GMT -6)   
Hmm that is an interesting delay. I went off for about 2 weeks, just to get some tests done without them, and I couldn't take it. The first 4 days had a slightly noticeable difference and then starting the fifth day it was just about the worst pain I've had. I completed the tests I needed but now I am back on full dose. It might not be great, but I prefer it over the immense pain of rebound.
Right Temporal Lobectomy 4/5/12

Diagnosed with GERD, Eosinophilic Esophagitis, and Epilepsy.
Studying biomedical engineering to research a better fix to at least one of them.

sunbeam48
Veteran Member


Date Joined Jun 2011
Total Posts : 795
   Posted 4/12/2013 3:31 PM (GMT -6)   
My rebound was pretty bad for about two weeks. I wasn't sure I was doing the best thing, but once I went that far, I didn't want to turn back. I'm so glad I hung in there. I tapered off PPI'S and stayed on zantec for a few months. I also had rebound getting off zantec, but it wasn't as bad and didn't last as long. Dogbones, I'm glad you are still working toward a Fast Tract diet. I'm not sticking with it anymore and I'm doing great! I eat carefully, but each meal includes carbs, fat and protein.

Pat Tall
Veteran Member


Date Joined Aug 2012
Total Posts : 950
   Posted 4/12/2013 3:54 PM (GMT -6)   
Here is PubMed article about rebound duration. You may have seen it already:
http://www.ncbi.nlm.nih.gov/pubmed/15679764

inpinkagony
Regular Member


Date Joined Mar 2013
Total Posts : 274
   Posted 4/12/2013 4:00 PM (GMT -6)   
DOGG: So I was diagnosed with LPR today I already suspected, I would see and ent if I was you but me and you could be different, I have a barium and 24 hr on the way to rule out how mild or severe my refluxing is but for now I need start on my diet and 130mg zantac so I can let my throat heal

Snowinsummer
Regular Member


Date Joined Jan 2013
Total Posts : 40
   Posted 4/13/2013 6:32 AM (GMT -6)   
Is the sensation of refluxate creeping up your throat part of acid rebound? I never, ever had this symptom prior to PPI use; it developed after about 8 weeks on PPI. I've been off all acid reducing meds for a month now... The burning from rebound is gone, but I have this annoying symptom. It's not painful, and I have no lump in my throat which leads me to believe its non-acidic reflux. I'm still closely tracking my diet to see if its related to a specific food (I cut out soy today). Has anyone experienced this and will it subside??
Thanks.

DOGGBONES
Veteran Member


Date Joined Apr 2012
Total Posts : 707
   Posted 4/13/2013 8:08 AM (GMT -6)   
Pat, thanks for the link, looks like this could last awhile.
 
Bacon, my stomach and throat (at times) feel like they have been sent to hell to burn. I'm going to stick this out as the ppis seem to now cause me just as many issues as not being on them.
 
snow, I don't have sensation of reflux creeping up throat but I have the stomach and chest burn off and on through out the day (lump comes and go's).

DOGGBONES
Veteran Member


Date Joined Apr 2012
Total Posts : 707
   Posted 4/13/2013 8:29 AM (GMT -6)   
pink,
I have lpr (lump in throat caused by non acidic reflux). (For me) ppis do next to nothing for lpr issues, as ppis address acid reflux not non-acid reflux (pepsin/bile). I have seen several GI's AND ENT's over the years and theres nothing else or new they can do for me other than add meds or surgery. They put me on max ppis and h2 plus gaviscon, tums, Carafate. I have worked my way off most of it (it all made me feel worst, not to mention the pharmacist looked at me like I was doomed).
 
sunbeam,
I will stay the course, though it may not feel like it I'm sure this is the right thing to do. Since joining here I've always "pushed" natural healing with diet and supplements, so I will continue to practice what I preach. That being said I will also continue to use Carafate and tums as an aid to get were I need to be. I'm sure you've had a endo over the years, how was the strength of your les? Does it work at all?

inpinkagony
Regular Member


Date Joined Mar 2013
Total Posts : 274
   Posted 4/13/2013 9:01 AM (GMT -6)   
Snow: I have no idea, but mine also came after the PPI's as well but I went to ENT and he confirmed I had LPR which make sense because I think I had LPR since july but I didn't know it since it's no acid reflux, I remember having sour taste mouth sores and recurring sinus infections, everyone has different symptoms when it comes to this particular disease, people can choke and cough and have asthma like symptoms. then some can have voice problems and sinus ear pains etc. The Lump in throat is swelling of the voice box or something but if yours is gone then you must have healed it but what type of symptoms are you having? you might want to read DR. koufman book dropping the acid I am following her diet starting today to see any improvement with lump and phlegm thing I am staying on high alkaline diet but this illness is a lot harder to beat with or without PPI get you some High alkaline water like essienta or evamore supposibly its suppose to kill the pepsin goes into our nose and airways and voice box causing damage. but the biggest hurdle is the bile how do we get rid of that. Pepsin lingers around after the digestion of proteins and all it needs anything below ph of 6.5 to activate it and the lower the you go the higher the activity of it is
bile is the biggest problem because there is no solution for this and it's not like you can stop it because any kind of fat in your diet it can be 2%DV meal bile is released to break it down causing it sometimes to reflux in our stomach up to our esophagus and when it lingers around causes LPR issues.

DOGG: how long have you had the disease?, its funny i think I had LPR before any of this started like i said above I had recurring infections of the sinuses and always wondered why i was congested and etc. but yeah the lump in the throat can be many things it can be caused by the stuff that lingers around but I have read some interesting stuff on the internet like your vegus nerve can be either irritated or damaged in some way so it causes it to malfunction so thats why we can have LPR, and LPR and anxiety really go hand and hand with me it might be the case but I will not know until some more testing to rule out how much I reflux and if my esophagus is working right and contractions etc. if everything comes back normal it could be nerve thing and I might want to look into some kind of medicine to let it heal, I heard a lot people had great relief with that. there are a lot of possibilities on why we have LPR we just have to explore those options have you ever had the 48hr testing done? I want to get the pill testing done and see if my stomach is not digesting things right because maybe that's why we have frequent refluxes. Sorry to rant but yeah I can agree with you pills or no pills you can not stop it the sad thing is you can stop the pepsin but the bile is what we can't get rid of and people had there gall bladder removed and it still comes. but what's the fast track diet? and I really hope you do get better, the acid rebound will go away trust me. and have you tried gaviscon advance for pepsin it said if you have low acid you might not get any results and you should try some akaline water to maybe kill of the pepsin it might be myth but anything above 8.8ph does the job, LPR is so hard to cope with I just want to fight it as much as possible before the surgery route. I just wonder how long the throat takes to heal I want my lump gone its worse in morning its like food is there or something.


I also know for me it could be nerve thing most of the time people who sing or use their voice excessively have overworked there vocal cords I remember i used to scream a lot when I was younger so I wonder for me if it could be a nerve thing, like nerves are just not working right and signaling the wrong kind of singles during the digestive process.
this is kind of interesting, telling us causes of LPR proves kind of my theory about nerves and other possibilities such as irritation from a endoscopy because I got mine after the endscopies.

http://stanfordhospital.org/PDF/otolaryngologyHeadAndNeck/InstructionsLPR_GERD.pdf

Post Edited (inpinkagony) : 4/13/2013 10:13:48 AM (GMT-6)


DOGGBONES
Veteran Member


Date Joined Apr 2012
Total Posts : 707
   Posted 4/15/2013 5:04 AM (GMT -6)   
pink,
I've struggled with gerd for about 17 yrs and lpr about 2 yrs or so. I think I've read and tried everything over the years. The fast track diet has a thread on this forum you can read more about in depth.

inpinkagony
Regular Member


Date Joined Mar 2013
Total Posts : 274
   Posted 4/15/2013 8:37 PM (GMT -6)   
DOGG: wow you have been going through it, good days and bad days I assume huh??? I am brand new to both actually, you know how me and you are experiencing odd symptoms since we came off the PPI, the things I gotten since I got out of PPI is chest tightness, chest pressure, sharp pains from time to time, lump in throat for 2 months now and sour taste for month in half the lump and sour taste are really bad in morning and it makes me think I am night time refluxer at my most, I am getting the 24prob done did you experience even worse symptoms after you got it and would you recommend me to go through it because every time I do any of these procedures I come out 10 x worse haha.

That's weird when did you first start experiencing your LPR was something that trigger it our like after test?

Yeah I saw the thing, so you eat for 5 days and fast for 2 days? have you had any progress with it? I just want to deal with LPR naturally but after all my testing I wont know and my ENT might recommend me some rigorous medication. I really think my LPR is from damaged nerves because I used to have like outbursts when I was younger where I would scream at the top of my lungs I know I sound crazy but I was teenager haha. But yeah I might see if that might be the cause if my tests come back normal and maybe experience with a lil of anxiety pills

Post Edited (inpinkagony) : 4/15/2013 9:30:41 PM (GMT-6)


DOGGBONES
Veteran Member


Date Joined Apr 2012
Total Posts : 707
   Posted 4/16/2013 5:02 AM (GMT -6)   
pink,
My lpr symptoms started a couple years ago after taking daily ppis. After I had my 24 hr ph test done I've always felt my upper throat has been a little different but I can't verify the testing was the cause.
 
I'm not a big fan of all the testing but it does seem to be a necessary evil.
 
The fast track diet has no fasting in it, you must of consused it with another. The diet has helped some but I haven't been on it long.

inpinkagony
Regular Member


Date Joined Mar 2013
Total Posts : 274
   Posted 4/16/2013 10:32 AM (GMT -6)   
Yeah, that's what happened to me, I wonder how can PPI lead to LPR wow if only I knew there was some kind of warning about it I would have stuck with zantac but at the time my esophagus was so inflamed I could only heal it but the PPI's

yeah I know, I am kind of nervous about this one, I think I am think long and hard about it before doing it.

Yeah maybe I am confusing myself with the wrong one.

I hope we both feel better soon. :)

DOGGBONES
Veteran Member


Date Joined Apr 2012
Total Posts : 707
   Posted 4/17/2013 11:53 AM (GMT -6)   
This is week 4 of no ppi's but only week 2 of rebound. Looks like I still have a ways to go.....ugh!

inpinkagony
Regular Member


Date Joined Mar 2013
Total Posts : 274
   Posted 4/17/2013 2:28 PM (GMT -6)   
GOOD LUCK DOGG you are not alone me and you are gonna beat our GERD/LPR naturally its comforting to know me and you are going through the same thing, my symptoms are getting worse but not too much, I still have the testing to do so I wont know what is the best treatment until mid may but for no I am start this fast track/ koufman diet. what diet are you following?

so how is it being off the PPI what kind of symptoms are you having? and I am starting to wonder if I have haitus hernia my doctor never told me anything but everything was good and you have mild irritation in esophagus so I guess I do not have one, but then within 2 weeks I started feeling LPR haha.

I hope we both get better :)

Post Edited (inpinkagony) : 4/17/2013 2:40:43 PM (GMT-6)

New Topic Post Reply Printable Version
48 posts in this thread.
Viewing Page :
 1  2 
Forum Information
Currently it is Tuesday, June 19, 2018 4:33 PM (GMT -6)
There are a total of 2,973,359 posts in 326,083 threads.
View Active Threads


Who's Online
This forum has 160960 registered members. Please welcome our newest member, Major_US_MARINE_SILENT1.
413 Guest(s), 7 Registered Member(s) are currently online.  Details
TheRhythm, Glascis, Girlie, NiceCupOfTea, Old Mike, Chander, Crazyick