Bad Side Effects - Dexilant, Reglan and Zoloft. Any advice?

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ErinNicole
New Member


Date Joined May 2013
Total Posts : 2
   Posted 5/7/2013 10:12 AM (GMT -6)   
I had a cortisone shot a number of weeks ago that caused a plethora of side effects, including my hormones being completely screwed up. This set off anxiety for me (which I have not had in over a year), which I was doing ok with on Xanax as needed (soon after the injection).

Recently, however, cortisone shot and the painkillers they gave me set off acid reflux. I don't have chronic reflux - when I get stressed or sick, I get it for a couple of days. Typically, I can nip this in the bud by taking a Prilosec a day for a few days, no problem. This was worse than any spell I've had before. First I was on Nexium, which didn't seem to help; I was then put on Dexilant (60mg/daily) and Reglan (before meals and bed) for loss of appetite. This latest prescription was this past Friday.

Saturday wasn't too bad, but Sunday was awful. Diarrhea, heart palpitations, anxiety that wasn't being touched by the Xanax, and eventually vomiting. Nausea has been preventing me from eating. The reflux is gone - I am just burping up a ton of air because I'm unable to eat and my stomach is empty.

Additionally, two weeks ago, the doctor put me on Zoloft - which I did not have a good history with (50mg/day). The last time this happened, I believe I began having suicidal thoughts, but she said this time might be different. I know a side effect of Zoloft is nausea and loss of appetite.

Yesterday (Monday), I called the doctor and she agreed I should stop taking the Dexilant and Reglan (which was now causing me to shake). I'd only taken six Reglan between Friday and yesterday. I also had an intense panic attack, and my fiancee took me to urgent care. The doctor there told me that the Reglan and Zoloft have a drug interaction, and that could be causing my shaking - she's having me stop the Zoloft.

My questions are:
1.) How long will it take for the Dexilant and its awful side effects (heart palpitations, hopelessness, anxiety, diarrhea, vomiting) to be out of my system? I've had one pill a day from Friday through yesterday.
2.) How long will it take for the Reglan and its side effects (similar to the Dexilant) to be out of my system? Six pills since Friday.
3.) How long will it take for the Zoloft to be out of my system? I've been taking 50mg once a day for just about two weeks, ending yesterday.

I want to be able to sleep through the night, get rid of my nausea, go back to work, concentrate, and get my appetite/strength back. I was hoping this would resolve itself quickly, as I haven't been on any of this for too long. Any insight would be much appreciated!

Thank you,
Erin

mudmagnetmum
Veteran Member


Date Joined Apr 2011
Total Posts : 1604
   Posted 5/7/2013 10:54 AM (GMT -6)   
Hi there

I think you need to ask a pharmacist regarding the half life of these drugs to get a more accurate response. We're not medics here, so can only help based on our own experiences. I went on and off Omeprazole because of side effects (skin) and I found it took only 1 or 2 days to observe improvement but maybe up to a week to be completely out of the reaction.

Have you tried Ranitidine (Zantac)? Or Gaviscon? I think steroids can cause gastritiis and it may be this you have had rather than reflux?

Another option would be to get a liquid version of a PPI so you can find the minimum dose that you can tolerate. Also Lansoprazole is available in half strength - 15 mg and could therefore be combined with Zantac by way of experiment. But you should talk to your PCP about these options.

MMM
GERD (3 years and counting)
Lifelong stuff: Food allergies/intolerance, eczema, asthma

Alcie
Veteran Member


Date Joined Oct 2009
Total Posts : 5028
   Posted 5/8/2013 7:29 AM (GMT -6)   
When I had a reaction to reglan it took a couple of months for the side effects to wear off after getting off the med.

Gastricman
Regular Member


Date Joined Jan 2013
Total Posts : 294
   Posted 5/8/2013 12:20 PM (GMT -6)   
Hi all,
 
IMO, stay away from Reglan (Metoclopramide) unless used for a very short duration.
The drug has many side effects, especially tardive dyskinesia, which may not resolve.
 
GM

ErinNicole
New Member


Date Joined May 2013
Total Posts : 2
   Posted 5/11/2013 6:34 PM (GMT -6)   
Thanks so much for the information! I started feeling a lot better this past Thursday, and things have only been improving. I'm never taking Reglan again!

TheSiXness
Veteran Member


Date Joined May 2012
Total Posts : 541
   Posted 5/11/2013 11:38 PM (GMT -6)   
reglan is an evil drug. Caused me a lot of depression, anxiety and heat flashes.
-TheSixness-

Fighting daily pain from gastroparesis, gerd and lpr!
Had the TIF done 2/2012 and still am symptomatic.

TheSiXness
Veteran Member


Date Joined May 2012
Total Posts : 541
   Posted 5/13/2013 11:05 PM (GMT -6)   
Reglan has a half life around 5-6 hours... I've stopped taking it 2 days ago and my body is still tingling and I can't concentrate anymore.
-TheSixness-

Fighting daily pain from gastroparesis, gerd and lpr!
Had the TIF done 2/2012 and still am symptomatic.

DOGGBONES
Veteran Member


Date Joined Apr 2012
Total Posts : 707
   Posted 5/15/2013 6:59 AM (GMT -6)   
Sixness,
Did UW prescribe the reglan?

TheSiXness
Veteran Member


Date Joined May 2012
Total Posts : 541
   Posted 5/15/2013 10:56 AM (GMT -6)   
Yes, but it wasn't our doctors, it was the surgery department.
-TheSixness-

Fighting daily pain from gastroparesis, gerd and lpr!
Had the TIF done 2/2012 and still am symptomatic.

TheSiXness
Veteran Member


Date Joined May 2012
Total Posts : 541
   Posted 5/15/2013 5:39 PM (GMT -6)   
Can reglan cause tingling in the hands and feet, plus a lack of being? My head is wild and i cant think, very confused. Havent taken in for a like 2 days.
-TheSixness-

Fighting daily pain from gastroparesis, gerd and lpr!
Had the TIF done 2/2012 and still am symptomatic.
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