Is PAR-2 the future?

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theacidrefluxman
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Date Joined Oct 2009
Total Posts : 739
   Posted 6/14/2013 10:19 AM (GMT -6)   
After a few doctors have mentioned that there are some drugs to be optimistic coming down the pipeline, I think I found a big one that they are referring to. Here is the abstract, and the link to the full article below.

Proton pump inhibitors (PPIs) are extremely effective for mucosal healing of reflux esophagitis, but less so for relieving the symptom of heartburn. PPIs block the secretion of gastric acid, the caustic effects of which have been assumed to be the primary culprit in the pathogenesis of reflux esophagitis. However, mounting data suggest that reflux-stimulated, immune-mediated mechanisms may underlie the development of esophagitis in patients with gastroesophageal reflux disease (GERD). Thus, the future of GERD therapy, particularly for patients who are refractory to PPIs, may be the targeting of proteins such as proteinase-activated receptor-2, which have central roles in the generation of immune-mediated esophageal mucosal damage and in eliciting the symptom of heartburn.

http://www.nature.com/ajg/journal/v105/n9/full/ajg2010272a.html

This is one of the reasons doctors are somewhat against surgery for many of us. If our disease is only of minimal cancer risk (especially for NERD/level A-B esophagitis bretheren), and surgery might not do the trick...then maybe it is better to hold out for a few years for some of these new ideas and options. It is a changing landscape and the dichotomy of surgery/no surgery and suffer might not be the best description of our options.
 
made link clickable

Post Edited By Moderator (dencha) : 6/14/2013 1:20:45 PM (GMT-6)


DOGGBONES
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Date Joined Apr 2012
Total Posts : 707
   Posted 6/14/2013 11:52 AM (GMT -6)   
I don't fully understand what it means or is saying? I also noticed the date was 2010, does that mean this didn't go further?

theacidrefluxman
Veteran Member


Date Joined Oct 2009
Total Posts : 739
   Posted 6/14/2013 8:21 PM (GMT -6)   
I've read a few articles on it, but just figured I'd post this one that I found today (I hadn't posted in a while).

No worries. I don't understand this one much either...I just look at the point that there is reason to believe it can help refractory heartburn sufferers, I guess through a different mechanism than that of PPI's, because it works in a different way...

Hope you are doing well bro, I hadn't been around in a while :)
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