NSAIDs shown to slow progression of Barrett's...

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GroverCat
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Date Joined Mar 2013
Total Posts : 174
   Posted 7/6/2013 12:52 AM (GMT -6)   
Caught this study via the NYT health page today, and thought it worth a look.


(I'm unfortunately allergic to NSAIDs, but I thought I'd share for folks who can pop them without getting hives.)


http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003553

phil-uk
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Date Joined Jul 2012
Total Posts : 190
   Posted 7/6/2013 5:39 AM (GMT -6)   
GroverCat, thanks for that info. It confirms an earlier 2007 study that came to a similar conclusion.

http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.0040067

I think we can possibly benefit by including food in our diets that contain Salicylates. [Assuming no intolerance or allergy] These are the active ingredient of some NSAIDS eg Aspirin.
Many fruits are rich in Salicylates. Olive oil is another good source.
 
Edit, Anyone able to get any info on the type of, and dose of NSAID?

Post Edited (phil-uk) : 7/6/2013 5:46:47 AM (GMT-6)


mudmagnetmum
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Date Joined Apr 2011
Total Posts : 1604
   Posted 7/6/2013 6:59 AM (GMT -6)   
I do wonder how they managed the study when most people with GERD can't tolerate Aspirin!!

MMM
GERD (3 years and counting)
Lifelong stuff: Food allergies/intolerance, eczema, asthma

Teacherman
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Date Joined Jun 2013
Total Posts : 172
   Posted 7/6/2013 7:51 AM (GMT -6)   
How much aspirin, what kind and when do I take it?
Also, what foods are are good. I read olive oil. That is good. I eat a lot of olive oil now. Every morning on my Ezekiel toast. I go to the olive connection and get their healthiest kind. Over 600 polyethnals. It is called piccal. Spelled it wrong.

phil-uk
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Date Joined Jul 2012
Total Posts : 190
   Posted 7/6/2013 10:34 AM (GMT -6)   
Just doing some quick research to see how much Salicylate is in various types of food.
There are numerous sites on-line for those who are intolerant, allergic or oversensitive to Salicylate but not many for those who are looking for benefit from dietary salicylate.
 
This site has some figures on Sal. content, originally from Australia in 1985,
 
 
Quantities are in milligrams per 100 grams.
 
e.g.  Fresh strawberry       1.36 mg/100g 
 
======= 
 
This article mentions a daily dose of 75mg Aspirin has been used in clinical trials,
 
 
"In 2011, British researchers, analyzing data from some 25,000 patients in eight long-term studies, found that a small, 75-milligram dose of aspirin taken daily for at least five years reduced the risk of dying from common cancers by 21 percent. "
 
To get the same benefit as one 75mg Aspirin from eating strawberries you would need to eat approx. 5.5kg [over 10lb]! (Edit- Figures altered, as I had got my decimal point in the wrong place)
 
So we would need to focus on those foods with the highest content of salicylates if we wish to increase our intake through diet alone.
 
Spices seem a likely contender, and I already take 1x400mg capsule of turmeric twice a day. From the site linked above...
 
Spices
======

Some spices can be extraordinarily high in salicylate, but are eaten
in such small quantities this is not often relevant.  Those that might
matter are: [mg/100g]

Cumin           45.0 powder
Curry          218.0 powder
Dill             6.9 fresh
Dill            94.4 powder
Garam masala    66.8 powder
Ginger           4.5 fresh
Mixed herbs     55.6 dried
Oregano         66.0 dried
Paprika, hot   203.0 powder
Thyme          183.0 dried
Turmeric        76.4 powder
 
I'm not sure I fancy eating nearly 100g of turmeric at one meal time!
 
I wonder what the minimum dose of Aspirin would be required for the same protective effect? I would guess that those with a lower BMI could take a smaller dose?
 
Still, this is good food for thought.
 
cheers all
phil
Edit btw maths is not my strongest subject, could someone check the figures to see if I have my decimal point in the correct place. Thanks

Post Edited (phil-uk) : 7/7/2013 2:37:10 AM (GMT-6)


caseysmom
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Date Joined Jun 2013
Total Posts : 21
   Posted 7/6/2013 3:15 PM (GMT -6)   
Please just be careful if you start taking NSAIDS on a regular basis.  I ended up in the hospital with 3 bleeding ulcers and the Dr. said the cause of the ulcers was NSAIDS.  I have fibromyalgia and was taking them everyday for the pain and according to my Dr., that was the cause and now all I can take is Tylenol, which doesn't work nearly as well as Aleve.  I miss my Aleve but because of GERD and the ulcers, I'm never to take them anymore. 

phil-uk
Regular Member


Date Joined Jul 2012
Total Posts : 190
   Posted 7/7/2013 3:07 AM (GMT -6)   
Caseysmom, You are right to point out the potential side effects.

But we are talking here about very low doses. The research mentions 75mg/day for chemopreventative effect, whereas when used as a painkiller/anti-inflammatory each tablet is 300-325mg, taken up to four times a day. [up to 1300mg/day, 17x the 75mg used as a preventative dose]
As pointed out in the above post, the dose from dietary Salicylate is likely to be even less.
 
Edit, there is a long term trial in the UK called 'AspECT'. This is comparing a number of different pharmaceutical strategies, including omeprazole/aspirin. This is now due to produce some interim findings.
 
http://www.octo-oxford.org.uk/alltrials/infollowup/aspect.html

Post Edited (phil-uk) : 7/7/2013 4:10:41 AM (GMT-6)


Teacherman
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Date Joined Jun 2013
Total Posts : 172
   Posted 7/7/2013 1:11 PM (GMT -6)   
Are they taking them at the same time? What time of time of the day do you take yours. With food or without? I just got some Bauer 81 mg. low dose. Do I just take one a day?

phil-uk
Regular Member


Date Joined Jul 2012
Total Posts : 190
   Posted 7/11/2013 2:44 PM (GMT -6)   
Teacherman, really, you should talk to your GP/Primary Doc about dosage.

You could google the AspECT trial, to get more info. I think they are using standard Aspirin tablets at 300 or 325mg.

Phil

opnwhl4
Forum Moderator


Date Joined Dec 2008
Total Posts : 4961
   Posted 7/12/2013 7:39 AM (GMT -6)   
Along with being hard on your stomach NSaids can also raise your blood pressure. Please talk with your doctor before trying this as GERD treatment.

I am no longer able to take NSaids due to past ulcers and them causing issues with my BP.

Take care,
Bill
opnwhl4
Moderator: GERD/Heartburn
Nissen 6/06 and 5/09
#3 on 8/24/11

Teacherman
Regular Member


Date Joined Jun 2013
Total Posts : 172
   Posted 7/12/2013 8:46 AM (GMT -6)   
Just saw my GI and asked about the daily aspirin. He said there is a wonderful study currently underway in England with about 11,ooo patients. He said they are testing at about 350 mg. of aspirin. but it is showing that it stops Barrett's in its track. Well, that is what they are hoping as I am. He said it looks promising. He said the 81 mg should be good.
I also got my impedance tests back. It was very good. I have very very low acid. He said the level would not harm me when refluxing. Not even close. The meds are working. I did the 48 hour bravo about 6 months ago and that too was a score of 1 out of 14. Very few reflux episodes. So why do I have Barrett'? either way, I asked his patholog dept. to look at my old slide from my original endoscopy. I had a small length. He Sid his pathology dept. would look t it and he would personally look at it as well. I had it ablated but it would be nice to find out I never had it???? Small odds but worth Try.
Aalto, spoke to him about the odds of EC after my ablation. He said I no longer have Barrett's. it's gone. My 0.16 odds over 16 years is actually less. Since I don't drink my odds are even better. Interesting all docs say heavy drinkers don't fair well with this cancer stuff. Also, since I don't have belly fat my odds are 50to 60 percent better. Something about belly fat and cancer, he said there mught be a connection. Not just the weight pushing down but more with the cells interaction. So my .016 is cut in half or more wich leaves my with a .08 or better and that is a near 0 chance of it returning. He said I could eat more and try different foods as the acid is not high. That will be nice. I can also lower my bed and try to sleep flat when I am feeling good. Not all Barrett's patients can do this. Long length need to be raised.
With that said I will be taking a break from my Internet blogging on the subject. I will check in from time to time and will post one last post on all the interventions that have worked for me in the last year. Last year at this time I was in horrible pain that lasted til January then it was intermittent and bothersome because its so scary. Good luck to all. And thank you for your help. I sure wish I knew about this site earlier than I found it.

gospa
New Member


Date Joined Jul 2013
Total Posts : 7
   Posted 7/12/2013 10:54 AM (GMT -6)   
congratulations teacherman.
i wonder though, if the big study is using asprin 300+, why your doc thinks 81mg might be very effective as well. I was just diagnosed with barrett this week and refuse to go on a PPI for the terrible long-term changes in the body. So I am strongly considering an aspirin regimen. I will ask the GI doc when he calls me with biopsy results. I wish the best for you. :)

phil-uk
Regular Member


Date Joined Jul 2012
Total Posts : 190
   Posted 7/12/2013 11:12 AM (GMT -6)   
Purely anecdotal, but an interesting and relevant story.

On discussing health matters with a client, [of mine] he mentioned that his heart doctor had taken him off Warfarin and put him on to a low dose of Aspirin instead [as anti-coagulation therapy]. I was then quite surprised when he said that his consultant had also added Omeprazole to counteract stomach problems that may be due to the Aspirin.

Post Edited (phil-uk) : 7/12/2013 11:36:42 AM (GMT-6)

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