LPR is a tricky diagnosis. Some here who have LPR also have a very sensitive esophagus, so although they get some relief with a Nissen, it isn't complete relief. From what I've heard around the forum, it definitely helps.
I had atypical/LPR reflux that was creating havoc with my lungs. My GI doc was very concerned that surgery wouldn't help, as my reflux levels were pretty low, and in or nearly in the normal range. Still, he was finally convinced (after 6 years of horrible lungs and a PCP who fought hard) to offer me the option of consulting with a surgeon, even though he was unconvinced of my need.
I had the surgery 3 weeks after I consulted with the surgeon and within 2 and a half months my lungs were healed. The surgery was a huge blessing for me.
So I guess my answer is yes, the surgery can help/cure LPR at least to a large extent.
Good luck finding a GI doc who thinks so as well!
Hang in there!
Nissen Fundoplication 2/09
"Whatever you fight, you strengthen, and what you resist, persists.”
“Worry pretends to be necessary but serves no useful purpose”
“Accept - then act. Whatever the present moment contains, accept it as if you had chosen it. Always work with it, not against it.”