How I beat my GERD...

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theacidrefluxman
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Date Joined Oct 2009
Total Posts : 739
   Posted 8/16/2013 7:22 AM (GMT -6)   
...Is a free book (see that, Koufmann) that I am going to write if I ever do beat it.

Whoever wants to write a guest chapter at the time will be more than welcome.

One day....right?

phil-uk
Regular Member


Date Joined Jul 2012
Total Posts : 190
   Posted 8/16/2013 2:28 PM (GMT -6)   
arm, I'll read it.

Yet another animal experiment reports stem cell based treatment leading to improvements in LES. When will a human trial take place?

http://onlinelibrary.wiley.com/doi/10.1111/nmo.12182/abstract

Background
Over the last 15 years, many studies demonstrated the myogenic regenerative potential of bone marrow mesenchymal stem cells (BM-MSC), making them an attractive tool for the regeneration of damaged tissues. In this study, we have developed an animal model of esophagogastric myotomy (MY) aimed at determining the role of autologous MSC in the regeneration of the lower esophageal sphincter (LES) after surgery.

Methods
Syngeneic BM-MSC were locally injected at the site of MY. Histological and functional analysis were performed to evaluate muscle regeneration, contractive capacity, and the presence of green fluorescent protein–positive BM-MSC (BM-MSC-GFP+) in the damaged area at different time points from implantation.

Key Results
with syngeneic BM-MSC improved muscle regeneration and increased contractile function of damaged LES. Transplanted BM-MSC-GFP+ remained on site up to 30 days post injection. Immunohistochemical analysis demonstrated that MSC maintain their phenotype and no differentiation toward smooth or striated muscle was shown at any time point.

Conclusions & Inferences
Our data support the use of autologous BM-MSC to both improve sphincter regeneration of LES and to control the gastro-esophageal reflux after MY.

theacidrefluxman
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Date Joined Oct 2009
Total Posts : 739
   Posted 8/16/2013 7:35 PM (GMT -6)   
Thanks Phil, interesting. I have no doubt that on a long enough timeline that will be the gold-standard treatment. Lets hope that we make it until then ourselves despite this medieval **** we have to deal with today.

phil-uk
Regular Member


Date Joined Jul 2012
Total Posts : 190
   Posted 8/18/2013 2:44 AM (GMT -6)   
arm, you contributed to an old thread that I have always kept book marked, discussing reasons for GERD. I have linked to it for the benefit of anyone who is interested.
 
"Weakened" LES 
 
I am sure some of the contents would make an excellent first chapter!
 
For me, I am hoping that at some point in the not too distant future, I will be able to find out if I would be a suitable candidate for Endostim.
 
All the best
 
Phil
 
Edited for clarity

Post Edited (phil-uk) : 8/18/2013 1:52:06 PM (GMT-6)


DOGGBONES
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Date Joined Apr 2012
Total Posts : 707
   Posted 8/20/2013 5:05 AM (GMT -6)   
At one time I posted a linked that sold "stem cell enchancers", however one of the mod's removed it. What it does is releases your own stem cell from your bone marrow, which then travel thru the body looking for damaged cells to repair.....I have not tried it.

theacidrefluxman
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Date Joined Oct 2009
Total Posts : 739
   Posted 8/20/2013 6:04 AM (GMT -6)   
DOGGBONES - that would scare me. I know of at least one theory that EAC is caused by stem cells at the esophageal junction going berserk. I'd be afraid of having stem cells running around my body. But I am no Dr (except perhaps a love doctor)., so who knows, maybe in a few decades that'll be the norm.

DOGGBONES
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Date Joined Apr 2012
Total Posts : 707
   Posted 8/20/2013 7:52 AM (GMT -6)   
ARM,
Why wait decades to share all that love.....write me a scrip now doc! lol
 
I agree, I'm not to sure how I feel about "stem cell enchancers" and don't care to be my own "lab rat". That being said, I think I might be open to getting stem cell injections at the les. I just don't think it's offered anywhere.....

phil-uk
Regular Member


Date Joined Jul 2012
Total Posts : 190
   Posted 8/20/2013 10:07 AM (GMT -6)   
Hi DOG, arm,

The truth about stem cell based medical treatments is that they are all with one exception, still very much in their infancy, and many professionals remain wary of the potential for long term problems. Until we see results from, and the start of more safety trials, (like those instigated by Reneuron [for Stroke patients] and Osiris [for non healing foot ulcers]), we are not going to see a stem cell based offering for GERD.

I would predict that the minimum timescale, from conception to clinic would be 10 years, although experience with other treatments could see a reduction.

I sincerely hope that restoration of the function of the natural ARB [anti-reflux barrier] becomes the gold standard for the future.

Cheers

Phil

DOGGBONES
Veteran Member


Date Joined Apr 2012
Total Posts : 707
   Posted 8/20/2013 11:00 AM (GMT -6)   
Thanks Phil,
Well here's to hoping...... :-)

hopegood
Regular Member


Date Joined Jun 2013
Total Posts : 93
   Posted 8/20/2013 11:14 AM (GMT -6)   
I watch closely at the advancements of stem cells and I am optimistic on the possibility of using stem cells to treat Gerd within a decade.
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