Different PPI's to use

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New Member

Date Joined Jul 2013
Total Posts : 4
   Posted 8/24/2013 5:55 AM (GMT -6)   
Hi there new to the forum and posted a few times regarding my issues with gerd/hiatus hernia, and found the feedback i have received has been great i am having a slight problem at the moment. I had to come off my usual doseage of 40mg Omeprazole daily to undergo the 24hr ph test and manometry test last week and have now had to resume taking the tablets again but before the test i had no side effects of acid reflux hernia etc.. but since stopping tablets for the test and now returning to them i feel they are not working anymore which is pretty bothersome because i have went from having virtually no side effects to now having daily symptoms.
My question to any users who may or may not have experienced this is what would be my best option to go for ? keep taking the omeprazole and it may just take longer to take effect or try another ppi combination ?
Thanks for any feedback i greatly appreciate it.

Veteran Member

Date Joined Dec 2008
Total Posts : 4961
   Posted 8/24/2013 7:48 AM (GMT -6)   

This is quite common for a PPI to stop working. I would ask your doctor about a replacement PPI or try pepsid OTC. Pepsid work pretty well for me when I was tired of taking a PPI and dealing with the side effects.

I had good results with Dexilant, Prevacid, and achiphex though before I tired of taking them.

Take care,
Moderator: GERD/Heartburn, Kidney disease

Nissen 6/06 and 5/09
#3 8/24/11

New Member

Date Joined Jul 2013
Total Posts : 4
   Posted 8/24/2013 9:10 AM (GMT -6)   
Thanks bill i will give them a try, very strange that it has stopped working after the 24hr ph study and manometry where as before i was taking them i had very minimum symptoms only when i was exercising, i suppose thats just the human body for you very strange things indeed.

In saying this i am scheduled to meet a surgeon this coming week in regards to my test results so this may well shed light on wether or not i require surgery to repair hernia and wrap my stomach or whatever the surgeon thinks is necessary, very agitated in regards to timing as i am supposed to be starting my training as a police officer in the coming months.


Veteran Member

Date Joined Apr 2011
Total Posts : 1604
   Posted 8/25/2013 3:18 PM (GMT -6)   
I have found after a flare up or medication withdrawal it can take up to 2 weeks for me to start feeling the benefit again. Sometimes you need to work on a flare up by adding something else in, like some Zantac or some Gaviscon, or you have to put back in other lifestyle measures that you know have helped you previously. I do find the effects of the PPI variable - sometimes I feel so good I wonder if I could reduce it, other times I feel so bad I wonder if I should be increasing it! One time it did take me 3 weeks to get back to where I was, so it may be a question of riding it out longer?

GERD (3 years and counting)
Lifelong stuff: Food allergies/intolerance, eczema, asthma
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