Can PPIs make chest pain worse??

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Thomas P
New Member


Date Joined Jul 2013
Total Posts : 10
   Posted 8/26/2013 2:42 AM (GMT -6)   
I am a 27 year old male. A year ago i started getting mild chest pain, it happend maybe once a week but was manageable. I'd also been coughing up sputum and throat clearing persistently for maybe a year before this.

My doctor thought it was GERD and put me on Lanzoprazole 15 mg. This took car of the throat clearing and coughing up of sputum but made the chest pain worse. It was more painful and more frequent. He increased the dose after a month to 30 mg and there was no was still no effect on the chest pain. He then put me on ranitidine 150 mg twice and a day and still no effect on the chest pain!

After an endoscopy should GERD, I'm back on Lanzoprazole 15 mg.

It's now close to 6 months of being on Lanzoprazole 15 mg and the chest pain is the worst its ever been. It's occuring daily now. Since I've started taking it my chest pain has really got unmanageable.

Can PPIs make chest pain worse? Could the chest pain be something other than GERD?

Thomas P
New Member


Date Joined Jul 2013
Total Posts : 10
   Posted 8/26/2013 11:19 AM (GMT -6)   
Anyone had a similar experience?

HurtsWorse
New Member


Date Joined Aug 2013
Total Posts : 1
   Posted 8/28/2013 8:48 AM (GMT -6)   
Yes, have tried 3 different PPI's and all were worse than the last. I never had heartburn/pain before this experience. I have "silent" acid reflux the Doc says so he gave me these as my voice was getting hoarse. Worse off than before as now I have rebound heartburn from taking the PPI's even though I quit all PPI's but I do not have the pain associated with the PPI's since stopping them. Have appointment to see about surgery since this medication is not the answer.

OHSOBAD
Regular Member


Date Joined Apr 2013
Total Posts : 87
   Posted 8/30/2013 7:23 AM (GMT -6)   
ThomasP - When does the chest pain start?  Is it constant? Have you had manometry and pH probe?  Are you seeing a GI doc or a family care doc?

SunnySkyJan
Regular Member


Date Joined Aug 2013
Total Posts : 38
   Posted 8/30/2013 7:54 AM (GMT -6)   
This is the worst of Gerd I've ever heard.  I guess I'll quit complaining!

Pat Tall
Veteran Member


Date Joined Aug 2012
Total Posts : 950
   Posted 8/30/2013 5:54 PM (GMT -6)   
Thomas P. there is another older gentleman on this forum that was taking medicines for his symptoms. Without much relief. (Sorry, I don't remember the specific details) but his doctor told him that gerd mimics heart problems and referred him for a heart test. He went to a cardiologist who did test. The next morning he had triple bypass. He credits his referring doctor for saving his life . I know you are young but have you had your heart checked out (like stress test). This is the first thing our doc did before starting PPI's . Kindest regards.

Thomas P
New Member


Date Joined Jul 2013
Total Posts : 10
   Posted 8/31/2013 4:44 AM (GMT -6)   
OHSOBAD said...
ThomasP - When does the chest pain start? Is it constant? Have you had manometry and pH probe? Are you seeing a GI doc or a family care doc?


Hi Oshobad,

Thanks for the reply.

I frequently get the chest pain in the morning after waking up but lately it has also been waking me up in the middle of the night. It mostly also occurs during the evening though I do sometimes get bouts of it during the day. The pain is located in the centre of the chest and radiates up to the neck. Its a constant soreness type of pain and can last for many hours and comes on slowly. The chest can feel cold when I get the pain and I get relief by applying hot compresses.

I haven't had a manometry or pH probe, only an endoscopy which showed Stage A esophagitis and mild gastritis but no hiatial hernia. There was no evidence of bile in my stomach when they did the endoscopy so my doctor thinks it must be acid reflux that damaged the esophagus.

I'm not seeing a specialist but a general practitioner.

Post Edited (Thomas P) : 8/31/2013 4:07:16 AM (GMT-6)


Thomas P
New Member


Date Joined Jul 2013
Total Posts : 10
   Posted 8/31/2013 4:50 AM (GMT -6)   
Pat Fill said...
Thomas P. there is another older gentleman on this forum that was taking medicines for his symptoms. Without much relief. (Sorry, I don't remember the specific details) but his doctor told him that gerd mimics heart problems and referred him for a heart test. He went to a cardiologist who did test. The next morning he had triple bypass. He credits his referring doctor for saving his life . I know you are young but have you had your heart checked out (like stress test). This is the first thing our doc did before starting PPI's . Kindest regards.


Hi Pat,

Thanks for the reply.

I've been referred to a cardiologist for a full cardiac exam and this is scheduled for 23 September. My doctor doesn't think it's cardiac because exercise doesn't really affect the chest pain but an ECG showed that my QT interval was slightly long so he thought it best to do a full check up.

Post Edited (Thomas P) : 8/31/2013 3:55:53 AM (GMT-6)

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