A recent article on Endostim

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hopegood
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Date Joined Jun 2013
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   Posted 9/23/2013 11:12 AM (GMT -6)   

Long-term results of electrical stimulation of the lower esophageal sphincter for the treatment of gastroesophageal reflux disease.

 
 
<Edit>  I hot wired your link  :-)   Thanks, Kitt

Post Edited By Moderator (stkitt) : 9/23/2013 12:48:39 PM (GMT-6)


stkitt
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Date Joined Apr 2007
Total Posts : 32602
   Posted 9/23/2013 2:07 PM (GMT -6)   
Very interesting article and thank you for providing the link.
~~Kitt~~
Moderator: Anxiety, Osteoarthritis,
GERD/Heartburn and Heart/Cardiovascular Disease.



"She Stood in the Storm & When the Wind Did Not Blow Her Away, She Adjusted Her Sails."

ericapeace2000
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Date Joined Mar 2012
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   Posted 9/25/2013 8:06 AM (GMT -6)   
Thanks for the information! I am always looking for research
GERD Moderator; Diagnosed GERD, no other medical conditions (this one is enough) ; Gluten free since 2012; low lactose since 2012

theacidrefluxman
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Date Joined Oct 2009
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   Posted 9/25/2013 8:43 AM (GMT -6)   
Wow, I hadn't paid much attention to endostim but that looks pretty impressive.

phil-uk
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Date Joined Jul 2012
Total Posts : 190
   Posted 9/25/2013 4:00 PM (GMT -6)   
Hi all.
 
There are at least two documented, on-going trials of Endostim.
 
I think 'hopegoods' link refers to this trial,
 
 
The other trial is this one,
 
 
The latter trial is an ongoing multicentre trial. I am a little confused as to which trial is which, so apols in advance if my info is incorrect.
 
I think this is a graphic of the results in 'hopegoods' link,
[edit, re-reading more carefully, I think the graphic includes long-term results from one and interim results from the other trial linked above.]
 
 
A trial in the UK is planned, to include those with Barretts, but this has gone quiet due to funding and other considerations. New Zealand has a small trial, and one of their cohort has been posting updates on the FORT website.
 
All the best
 
Phil

Post Edited (phil-uk) : 9/25/2013 3:20:51 PM (GMT-6)


hopegood
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Date Joined Jun 2013
Total Posts : 93
   Posted 9/26/2013 11:24 AM (GMT -6)   
There is an interesting result from the clinic trial----some patients switch off Endostim, their Gerd symptoms seem not come back as pre-op. Is electronic simulation able to "restore" LES function?

Gastricman
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Date Joined Jan 2013
Total Posts : 294
   Posted 9/26/2013 12:06 PM (GMT -6)   
Hi.
 
hopegood wrote:
 
"There is an interesting result from the clinic trial----some patients switch off Endostim, their Gerd symptoms seem not come back as pre-op. Is electronic simulation able to "restore" LES function?"
 
I would think that this would be possible since the Endostim pulses tighten the LES.
Therefore, the LES musculature becomes stonger - at least for the short term, I think.
 
GM :)
 
 

phil-uk
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Date Joined Jul 2012
Total Posts : 190
   Posted 9/26/2013 3:08 PM (GMT -6)   
Hi hopegood,

I also think you are correct, that the benefit of the device continues for some time, in the short term, after it is switched off.
This is how it manges to be an effective treatment, in-between the half-hourly stimulations.

Bring it on! :)

There must be hundreds of thousands of patients worldwide, that could benefit from this device.

Regards

Phil

GC1pink
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Date Joined Nov 2012
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   Posted 10/14/2013 2:47 PM (GMT -6)   
Phil-UK

Did you ever figure out a way to stimulate the LES externally?
Hypothyroidism, Glaucoma, Dry Eye Syndrome, Positional Vertigo

"I am simply stunned...that is this age of technology not one company or individual has managed to make a valve that could be placed BELOW the LES to STOP reflux!"

phil-uk
Regular Member


Date Joined Jul 2012
Total Posts : 190
   Posted 10/14/2013 3:20 PM (GMT -6)   
Hi GC1pink, I'm still waiting for the patient selection for our trial in the UK to begin. It was at this initial meeting I was planning to raise the subject of the potential of an external pad.

It's not something that I would try and make at home, although I think it would be possible to construct one. The worry being that it is physically quite close to the heart, and if the pad slipped, or the output was too high, it could cause problems. I have recently contacted Endostim's distributors and they have said that there are other doctors [other than those associated with FORT] in the UK looking to start trials.

Endostim has also appeared on the NHS Horizons website. I am hoping this will trigger more interest.

All the best

Phil

Post Edited (phil-uk) : 10/14/2013 2:23:03 PM (GMT-6)


GC1pink
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Date Joined Nov 2012
Total Posts : 532
   Posted 10/15/2013 9:52 AM (GMT -6)   
Hi Phil,

I'm very interested to hear that Endostim has appeared on the NHS Horizons website, and I do hope that you can get on a trial.

I apparently have a very long esophagus - it's nowhere near my heart actually the Gastric Junction is about 3 inches above my belly button. I have tried contacting Endostim for more information about the amplitude strength but they have not replied. Do you have any information regarding this?

My God I wish there was an external pad.

Many thanks,

Glennis
Hypothyroidism, Glaucoma, Dry Eye Syndrome, Positional Vertigo

"I am simply stunned...that is this age of technology not one company or individual has managed to make a valve that could be placed BELOW the LES to STOP reflux!"

phil-uk
Regular Member


Date Joined Jul 2012
Total Posts : 190
   Posted 10/15/2013 2:07 PM (GMT -6)   
Hi Glennis, the amplitude strength used is beyond me.

If I were thinking about trying an external system, I would begin with an existing muscle stimulation system, and set the parameters accordingly. There would be many variables, such as position of the pad, duration of the stimulation, strength of stimulation, frequency of stimulation etc. Trial and error would be involved and settings would have to be arrived at in an empirical way. If you were to try this method, one could start with lowest settings and work up.

I would not try this without professional help. There may well be people with experience of EMS that could help you. The commercial Slendertone system could be a starting point.

Cheers

Phil
 
PS, you could end up developing a great six-pack! lol

GC1pink
Veteran Member


Date Joined Nov 2012
Total Posts : 532
   Posted 10/15/2013 4:35 PM (GMT -6)   
Hi Phil,

I don't think I'm brave enough to mess around with my sphincter, it's pretty useless as it is, I think I'll leave it to the experts, so if you do get to ask them about the external pad, do let us know.

all the best,

Glennis
Hypothyroidism, Glaucoma, Dry Eye Syndrome, Positional Vertigo

"I am simply stunned...that is this age of technology not one company or individual has managed to make a valve that could be placed BELOW the LES to STOP reflux!"
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