Our bodies have a hormone known as gastrin. Gastrin is what controls the amount of acid our stomach produces. When taking H2-blockers and PPIs, it tends to make our gastrin levels go up. The longer you are on these medications the more your gastrin levels will go up. The reason this is is because your body doesn't think you are producing enough acid because the food isn't breaking down properly. When stopping the medications, there is nothing that is blocking the acid from being produced so now because of the high gastrin levels, you are over producing acid which results in stronger symptoms than before. I was on different PPIs for almost 8 years and cut them cold turkey after finding out a lot of bad things about them. The first week was by far the worst for me. Through bad diets or possibly life changing events, your body may have changed which results in getting GERD or LPR. The good thing about our bodies is that given the correct diet and care, it can heal itself. I am currently going through this process myself. So far it seems to be working. I'm currently 7 weeks off PPIs, just take a very small dose of H2-blocker at bedtime to help with LPR symptoms, and as the weeks go by, I feel the progress. It can take time for your body to heal. I think we expect immediate results due to how fast medications tend to mask symptoms to make the pain go away. I'm going down a more realistic approach of 6-12 months for my body to heal itself.