Hello and welcome to HealingWell.
I have read that missing a couple doses of PPI can cause an increase in acid production and rebound of severe symptoms. It is possible that is what happened even after missing only one dose.
Hopefully another member will be along to help with your question.
~~Kitt~~Moderator: Anxiety, Osteoarthritis,
GERD/Heartburn and Heart/Cardiovascular Disease. "She Stood in the Storm & When the Wind Did Not Blow Her Away, She Adjusted Her Sails."