Prilosec and Pepcid Question

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Regular Member

Date Joined Dec 2013
Total Posts : 40
   Posted 12/29/2013 4:06 PM (GMT -6)   
I was diagnosed with gastritis (from upper endoscopy) last year, and I think I still have it. I've never had actual "reflux", but sometimes the acid feels like it's eating into my stomach, and other times I'm bloated and burpy.

I started taking Prevacid 15mg in 2003 when I had this before (it took almost 2 years to go away), and I was on it every day until 2007 when I switched to Prilosec OTC (20 mg), which I've been taking every day. Last summer I weaned off the Prilosec over 3-4 months. Acid rebound wasn't horrible, but a few months later I got gastritis. I never should have stopped taking the Prilosec.

So now I take Prilosec OTC in morning, and 2 Pepcids throughout day (10mg x 2). Acid blockers inhibit absorption of nutrients, and I have osteopenia (precursor to osteoporosis). I'd like to quit the Pepcids, but after being on them every day for 8 months, even removing 1/16 of one pill creates horrible acid rebound for days afterwards.

This is a daily source of stress for me, as the Prilosec alone no longer works in keeping the acid at bay. If I continue taking the Prilosec plus the Pepcid, then if I get gastritis again, I'll have to take even more, and so on. I don't want to get to the point where I'm taking huge doses of this stuff and then I can't get off it because the acid will burn a hole in my stomach.

Does Prilosec 20mg + Pepcid 20mg every day seem like a lot, especially if I have to continue on it for the rest of my life? I'm a bundle of nerves over this.

Regular Member

Date Joined Aug 2013
Total Posts : 97
   Posted 12/29/2013 4:26 PM (GMT -6)   
My doc had me on 40 mg/da of Prilosec and from what he said, its a normal adult dosage. 20 mg is not. I was also on 60mg Dexilant delayed release last year.

Be sure to take B12, magnesium chloride and calcium citrate supplements if you need to remain on PPIs for over a few months.

If PPIs are the only was to relieve your symptoms, you may have no other choice at this point in time.

Just a thought...have you tried H2 blockers? I use them when I feel any gastritis coming on and it seems to help during the weening process.

Also you may need to try another GI doctor as they seem to have varied opinions on this stuff!

Fifty years with GERD

Regular Member

Date Joined Dec 2013
Total Posts : 40
   Posted 12/29/2013 5:18 PM (GMT -6)   
I drink Boost and Resource 2.0 which have extra vitamins and minerals, and I do take a B complex supplement. Pepcid (Famotidine) is an H2 blocker, and I'm taking 20mg a day (10mg x 2) in addition to the Prilosec.

Every drug site I read (like and says that 20mg is a standard adult dose, but 40mg is a dose for an ulcer. And of course they all say to not take it beyond 8 weeks. Yeah sure, try 8 years!

GI doc said I should go on Nexium, but I think Nexium, Prilosec, and Prevacid are all basically the same, it's really the dosage that makes the difference. Another doc said Dexilant. How long were you on Dexilant and did you get acid rebound when you quit? Are you on anything now?

Veteran Member

Date Joined Dec 2008
Total Posts : 4961
   Posted 12/30/2013 11:19 AM (GMT -6)   

The different PPIs are a bit different. I didn't have very good results with prilosec or nexium, but had very good results with prevacid and dexilant.

Before I had surgery I was taking 40mg twice a day.

Take care,
Moderator: GERD/Heartburn, Kidney disease

Nissen 6/06 and 5/09
#3 8/24/11
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