If you are on PPIs or H2 blockers, or even regular use of antacids like Tums, Mylanta or even Gaviscon, then the Ph of your stomach may be too high to allow production of pepsin. The smell or taste of food triggers the release of HCL which will bring the Ph level to less than 4, which then allows the release of pepsin. If it never gets to less than 4 because of acid suppressing drugs, you'll get no pepsin, and a negative result on the test. At least that's the theory.
Which still leaves you with the ultimate question of what is causing the burning in your throat. I wouldn't dismiss the bile theory just yet. While you are right that there should be a little acid with the bile, if the acid suppressing drugs are working, there would be very little - not enough to reach a Ph level of 3 or less, and therefore - No Pepsin.
Good points; before I took the latest samples I ceased all medications for 96 hours
- the minimum needed according to RDBiomed is 48 hours
- so no H2 Blockers, no Gaviscon and no Mirtazapine, although the first and last ones were already stopped anyway. In that regard, I really hope the 24 hour probe can detect what is really happening. Bile reflux apparently does have a link to stress, so if it is the culprit behind my problems at least I have a chance of relieving it, if not curing it. It would also explain why the antidepressants work on my symptoms much better than any PPI/H2 Blocker/Antiacid ever has.
Oh also, I was on Cimetidine during my first 3 samples, and pepsin was still detected. Apparantly H2 Blockers don't affect the release of pepsin. I was also on Gaviscon Advance back then too; as far as I can tell, neither of them did anything to prevent a positive result. :p I found these too; do they sound like valid theories?
The 2nd one talks a lot about
Vitamin D3, but I'd consider that theory a bit of a hoax. I've been on 1000 - 6000 IU for a whole year. My D3 levels were already high enough to "cure" LPR when I started out, and have only gotten higher since. It hasn't made a jot of difference for me. And if it is all about
"acid vapours" how on earth do I stop them? I always have to burp, and if burping causes LPR then I'll never get rid of it ;(
EDIT: Just found that the pH needed to create pepsin initially can be up to ph 5, so there's a slightly larger margin there for its creation. Any higher, and I doubt ANYTHING would be digested at all, antiacids or not :)
Post Edited (Daxter) : 3/4/2014 1:28:22 PM (GMT-7)