There are many members who have experienced side effects from being on PPIs, myself included. I was on them for 10 years and it contributed to symptoms of IBS as well as muscle twitching. I am on OTC Pepcid AC 2 times a day and I feel better off the PPIs. I also added in probiotics and it has helped. Try alkaline water and changing your diet to a low acid diet to manage your reflux. I follow the LOWFODMAPS diet and it is helpful. PPIs can produce issues over time.
GERD Moderator; Diagnosed GERD, possible IBS; Gluten free since 2012; low lactose since 2012