Reducing Omeprazole

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Croftboy
Regular Member


Date Joined May 2014
Total Posts : 71
   Posted 7/19/2014 9:59 AM (GMT -6)   
I have been on 40 mg for 4 weeks having moved from 10mg (7 years) to 20mg for 4 weeks then 40. I want to get down to 20 again as I have felt worse generally on the higher dose with (i think) more symptoms caused by the drug than the reflux inc increased burping and flatulence ( we are fun to be around aren't we?)
I was fine and symptom free for 3 weeks on 40 then v mild gripey/crampiness for a couple of dyas then fine so decided to cut down to one dose a day on Thursday-fine also fine Friday and eating and drinking red wine like a champ -off for a meal tonight and ... typical have been upset stomach/bowel today -so wonder if i cut it too soon -any advice? Im going to take a 20mg before we go out as my wife has been looking forward to this meal (and I have cancelled twice already due to stomach) and hope Im ok.
Had an ultrasound on Thursday -no gallstones - but back to discuss with Dr on Friday and hoping nothing else shows up
cheers

James_a
Regular Member


Date Joined Jan 2014
Total Posts : 97
   Posted 7/19/2014 10:41 AM (GMT -6)   
hi

it sounds like either your underlying condition has worsened requiring a higher dose or you have built a tolerance to omeprazole requiring a higher dose. I could not tolerate omeprazole and at 60mg i could not breath well and laboured, when i switched to nexium my i had no side effects, well not much or as serious as omeprazole. I was very hesitant not to take nexium because its basically only the right enantiomer of omeprazole (S). Omeprazole is basically a 50-50 mix of left and right enantiomer, the left enantiomer is tuned into the right enantiomer when its metabolised by hour body, but this conversion is not consistent and person dependent, roughly speaking try nexium 20mg and see how that works for you, discuss this with your doctor. There quite a few of them in the ppi family.
Lansoprazole, pantoprazole, dexilant, rabeprazole. I hate them all personally but unfortunately its trial and error with them.

goof luck

Croftboy
Regular Member


Date Joined May 2014
Total Posts : 71
   Posted 7/19/2014 11:03 AM (GMT -6)   
cheers thanks -I think its a tolerance thing-i have friends which have had the same and perhaps as you get older (im now 57) the sphincters wear out (!)
Im in UK and I don't think we can get Nexium here on the NHS-does anyone know if that is correct?

James_a
Regular Member


Date Joined Jan 2014
Total Posts : 97
   Posted 7/19/2014 11:53 AM (GMT -6)   
you can get nexium but unfortunately the NHS doctors will not prescribe it for cost treason. They always try omeprazole first, then either pantoprazole and lansontoprazole, then nexium after they exhaust the 3 options first. Nexium still has its patent so no generic manufactured drug availed to NHS. I think nexium cost NHS 8x more than omeprazole, but don't quote me saw this figure thrown around last time.

Croftboy
Regular Member


Date Joined May 2014
Total Posts : 71
   Posted 7/19/2014 12:22 PM (GMT -6)   
Oh very interesting - i cancelled my meal tonight so feeling a bit sorry for myself and hoping the 20mg will kick in soon
cheers

Croftboy
Regular Member


Date Joined May 2014
Total Posts : 71
   Posted 7/19/2014 12:31 PM (GMT -6)   
James I meant to ask you to explain the 'right/left entantometer ' thing sounds very technical -so either you have done the research or you are in the biz??

Mommanoesbest3391
Regular Member


Date Joined Jun 2014
Total Posts : 64
   Posted 7/19/2014 1:40 PM (GMT -6)   
Hey Croft

We're in the same boat, been on PPI for 4 weeks , two of Nexium and two Losec ( omeprazole). Starting to feel like 20mgs twice a day is also making me like crap honestly. This is my second big flare in 3 1/2 years and I also think maybe omeprazole has become used to my body. Got some nausea still, not 100% on omeprazole eating wise and I'm counting the days till I reduce to one 20mg. Nexium was one PPI I couldn't tolerate where as my sister has been fine on it for many many years. Different strokes for different folks , feel better soon ! :)
-Take care of your mind and body so that your soul will be tempted to stay-

GERD with laryngoesophagitis
Intercostal Neuralgia 2012
General Anxiety Disorder
Lactose Intolerant


Losec 20mg twice a day (restarted July 2014)
Ativan 1mg since 2011 for body/ GERD spasm and sleep as needed.

Croftboy
Regular Member


Date Joined May 2014
Total Posts : 71
   Posted 7/19/2014 1:58 PM (GMT -6)   
Hey mommanoesbest -hope you feel better soon as well-i was feeling quite optimistic that i had stabilised it until today and once again feel terrible with gastritis and dizziness etc -Im dreading going back to the dr as she will probably make me have an endoscopy which terrifies me !
I do think that since i have increased my dose of omeprazole i have felt more anxious, worn out and generally unwell apart from brief periods -its odd as i tolerated the low dose (10mg) for 7 years with no probs at all.
Hope you have a better time x

Mommanoesbest3391
Regular Member


Date Joined Jun 2014
Total Posts : 64
   Posted 7/19/2014 2:21 PM (GMT -6)   
I'm pushing forty so I hear ya :) And omeprazole worked like a charm the first flare, this time it's exasperating. I'm scared foe all tests, any tests but I know my body sometimes forges on without me. I've had all other tests except the endoscopy, my body fights the tranquilizers way to easy, very bad I know but part of my anxiety disorder. I am following Drop the Acid diet which I think helped quit a bit if I look back to my journal of my first flare compared to this journal and also intend to try natural remedies as so many others have. I also take an anti nausea pill at lunch time here and there, seems to help. Keep posting of results, good to know we aren't alone :))
-Take care of your mind and body so that your soul will be tempted to stay-

GERD with laryngoesophagitis
Intercostal Neuralgia 2012
General Anxiety Disorder
Lactose Intolerant


Losec 20mg twice a day (restarted July 2014)
Ativan 1mg since 2011 for body/ GERD spasm and sleep as needed.

Croftboy
Regular Member


Date Joined May 2014
Total Posts : 71
   Posted 7/19/2014 2:37 PM (GMT -6)   
Deffo not alone! I have to say i really feel for some of the poor people who post on here who seem to be suffering worse than I am. I haven't been right though since April and the paranoia is now kicking in!!
Take care of yourself x

James_a
Regular Member


Date Joined Jan 2014
Total Posts : 97
   Posted 7/19/2014 2:55 PM (GMT -6)   
Hi

Thankfully I am not in the business of distributing or medical doctor. I do have a keen interest in quantum physics and quantum chemistry in general. I can read biology and their associated research papers quite easily even though its not my field. I have spent the last year researching on the mechanism by which acid is produced and on detailed chemistry, physiology and mechanism oh how the gastro intestinal system works. By no means is my knowledge complete or i am qualified enough to give medical advice, i always advise you to consult doctors on the matters but lets say I has some very incompetent doctors that almost killed me if i did not take matters into my own hand. The new breed of doctors are unable to think outside the box. I regret not doing medicine now, i wish i could help people from these new breed of doctors. Lets say 3 consultants and 4GP made my life a living hell by listening to them. The ppi were playing havoc with my nerves and me.

enough of my rant, but basically omeprazole is composed of 2 molecules. If you took one molecule and reflected it into a mirror you get the other but are not superposable (Very simplified explanation here). In chemistry these are called enantiomer and have usually different chemical properties specially when considering human body. Omeprazole is a racemate meaning its there in equal amounts of both enantiomer. You have a S and R Omeprazole in 50-50 mix. The S is actually the active part in omeprazole while the R not effective, but in this case the R is converted to S enantiomer by the body using cytochrome p-450( well its CYP2C19 isozome of cytochrome p450). But this conversion(chiral shift ) process differs in different people, hence why some people find nexium more effective than omeprazole.

good luck

Croftboy
Regular Member


Date Joined May 2014
Total Posts : 71
   Posted 7/19/2014 3:29 PM (GMT -6)   
thanks James a very cogent reply-sorry to hear about your troubles with the medical profession-lm guessing you are in the UK as well?? As is often the case unfortunately its a bloody lottery isn't it?If we are lucky we get someone who actually cares about people -i know from my own experience as a nurse this is not always the case sadly
take care

Mommanoesbest3391
Regular Member


Date Joined Jun 2014
Total Posts : 64
   Posted 7/20/2014 7:09 AM (GMT -6)   
I agree with your statement James_a, molecules do play differently on people even if medications have the same ingredients. I am sad when I hear doctors and pharmacists speak of these medications like they are candies to be taken liberally at our discretion. You would think pharmacists who have more experience in medical drug dispensing would know more but on my end they are on same wavelength as doctors as to effects/symptoms etc. We are short on doctors in my province more so good ones, specialists etc. It is a hit and miss thing I agree and by trial and error I learned on my own (no doctor or pharmacist) that my organs can't assimilate certain molecules of certain drugs and certainly not generic brands which costs more for me in the end. But I trudge on like a little soldier :)) Have a good one guys!
-Take care of your mind and body so that your soul will be tempted to stay-

GERD with laryngoesophagitis
Intercostal Neuralgia 2012
General Anxiety Disorder
Lactose Intolerant


Losec 20mg twice a day (restarted July 2014)
Ativan 1mg since 2011 for body/ GERD spasm and sleep as needed.

ericapeace2000
Veteran Member


Date Joined Mar 2012
Total Posts : 1110
   Posted 7/25/2014 10:30 AM (GMT -6)   
Check into IBS, some of your issues could be both GERD and IBS. I developed symptoms of IBS from takling a PPI for a number of years. It messed with my digestion. I now take Pepcid AC over the counter.
GERD Moderator; Diagnosed GERD, possible IBS; Gluten free since 2012; low lactose since 2012

Mommanoesbest3391
Regular Member


Date Joined Jun 2014
Total Posts : 64
   Posted 7/25/2014 11:45 AM (GMT -6)   
Hey guys:)

Update for me and might help or offer encouragement. I'm on day two of weaning off Omeprazole (Losec here in Canada) from 20mg twice a day to once. I was feeling so very wrong on it, loss of time, moody crying, my digestive system took a major hit this time around and I just couldn't take it anymore. I will look into IBS thing as ericapeace2000 said, thanks for that info:) But I do feel better of of it...I'm more aware but now it's to heal my digestive problems a little at a time and and transit on Zantac OTC for a couple days. Hope you guys are well, please take care and keep posting updates..feels less lonely :)
-Take care of your mind and body so that your soul will be tempted to stay-

GERD with laryngoesophagitis
Intercostal Neuralgia 2012
General Anxiety Disorder
Lactose Intolerant


Losec 20mg twice a day (July 2014) and tapering off
Ativan 1mg since 2011 for body/ GERD spasm and sleep as needed.

ericapeace2000
Veteran Member


Date Joined Mar 2012
Total Posts : 1110
   Posted 7/28/2014 6:22 PM (GMT -6)   
Good to hear you are feeling better! I also felt better being off the PPI. I still deal with migrating rib and back pains but it better.
GERD Moderator; Diagnosed GERD, possible IBS; Gluten free since 2012; low lactose since 2012

James_a
Regular Member


Date Joined Jan 2014
Total Posts : 97
   Posted 7/29/2014 8:06 AM (GMT -6)   
So glad to hear things are looking well for you both, i too am off PPI unfortunately for me, i had no choice and they were making me very ill, It flared my gastritis back up and in my 3rd week almost. I was taking sucralfate but because of sever gallbladder pains I have stopped that and my tapering dose amitriptyline and even gaviscone and tell you what i am so busted up right now but in positive spirit that i actually managed to get of PPI. The sucralfate really helps with gastritis, , with stomach pains, and worst amitriptyline withdrawal symptoms,it might not be 2ffective like PPI but its the closes thing to natural you are going to get. Ask your doctor to prescribe it or the liquid version if you can rather than tablets, it does not much for pain reduction but trust me its effective and certainly more than Zantac there studies done in Italian hospitals which sucralfate was more successful at curing gastritis in 8 weeks than Zantac and it does not get metabolised by your body but excreetedbout by your kidneys - take care if you sensitive to aluminium please discuss with you health care provider. Talk with your GP about taking it, shame i could not continue with it, remember most think it does nothing because it does not too much for pain but its next best thing to the horrid PPI.

It also stimulates stomach mucosal production and also bicarbonate production and other benefits that are still debated on.

good luck all, hope you a speedy recovery.



good luck all

ericapeace2000
Veteran Member


Date Joined Mar 2012
Total Posts : 1110
   Posted 8/4/2014 5:37 PM (GMT -6)   
How is everyone doing?
GERD Moderator; Diagnosed GERD, possible IBS; Gluten free since 2012; low lactose since 2012

Mommanoesbest3391
Regular Member


Date Joined Jun 2014
Total Posts : 64
   Posted 8/7/2014 7:00 PM (GMT -6)   
hi ericapeace:)

I'm doing so so, I think I may have gastritis and I've been bumped up speedily to a gastro doctor next Tuesday. I'm loosing too much weigh and all I can hold down is water and watered down soup. Something is really out of wack here. I hope everyone is better than I and I keep you in my thoughts and prayers.
-Take care of your mind and body so that your soul will be tempted to stay-

GERD , Gastritis??
Intercostal Neuralgia 2012
General Anxiety Disorder
Lactose Intolerant

Zantac twice daily 150mg
Losec 20mg twice a day (July 2014) stopped July 25th
Ativan 1mg since 2011 for body/ GERD spasm and sleep as needed.
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