It really depends on the dosage of prednisone and how well you tolerate it, also it depends how bad the inflammation is and where it is. Prednisone is a cox2 blocker, its often described as selective blocker and was made to reduce the effect on prostaglandin production, but very roughly it blocks or seriously inhibits the production of prostaglandins that is required in the upkeep of mucosa production in the stomach and several other places, hence it can and does cause ulcers and gastritis. There is also some theory that it can relax the oesophageal valves but i have never seen such or evidence for it, neither have i researched it extensively.
I am by no means a qualified doctor but I have never seen it given for the type of inflammation you are complaining about
. Its certainly possibly to try a shot 5-7 day course but i seriously, seriously doubt its benefits will be sufficient enough if any to impact your quality of life.
Liquid sucralfate and gaviscon will be much better alternative if you don't want to take ppi or you could even add a H2 blocker, which are more gentle than PPI and much easier to wean off. There is ranitidine, cimetadine and fomatadine to try. If your GERD is not controlled then you will be going round in circles, with constant burning of the oesophageal valve and oesophagus. The Sucralfate binds to the damaged area and helps form a protective barrier, the Galviscon is both antacids acid and alginate which is to form a barrier on top of food to prevent further reflux. The sucralfate is very useful and don't know why doctors don't prescribe it, its wonderful medication that is not metabolised by your body but excreted by your kidneys but this does not mean it is side effect free, those intolerant to aluminium should take with caution or doctors permission but its well tolerate. Its protective qualities of protecting the inflames areas by up to 8 hours is in my opinion just as important as the ppi in healing by reducing acid. In one large Italian study sucralfate was more effective than Zantac in curing gastritis or severely reducing it the the 8 week mark.
So a combination therapy in my opinion is more full proof. Some have very reactive stomach, any inflammation directly under or above the osapheageal valve can lead to it
opening involuntary, certainly was in my case. When i took sucralfate it certainly did not seem to work, but after 1 week its effects were quite noticeable. Some with ulcers find ppi/H2 blockers more effective in pain reduction than sucralfate but its barrier forming qualities are very efficient in promoting the healing process.
Then main problem with it is fitting it into your schedule, must be taken 1 hour before meals and up to 4x a day, normal dose is 1g x 4 a day. with maximum dose of 8g a day. Please consult with your doctor but make sure you get the liquid version as its more effective for oesophageal damage by coating it.
You will fine the triple combination will being you quick relief, but please discuss with your doctor. Hope fully you can control your symptoms with just diet changes like before.
all the best if luck
Post Edited (James_a) : 7/30/2014 3:45:21 AM (GMT-6)