Chronic gastritis..Prilosec vs Nexium

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New Member

Date Joined Sep 2014
Total Posts : 1
   Posted 9/1/2014 6:54 AM (GMT -6)   
My first post since joining .. I have had chronic gastritis( hospitalized twice ) After an endoscopy a few months ago, he said my esophagus was ok but lower stomach affected. Stress is my trigger.. As a family caregiver not much I can do about my situation, accept staying positive and remembering to take care I'd myself, too:) my doctor recommended Prilosec 40 mg when major flare up.. But takes awhile to kick in. Anyone use Nexium ? Nausea and constant feeling of feeling I'm going to vomit iSync biggest issue. Thank you all so much. Also, what about Sucralfate in combination with above meds ?

Regular Member

Date Joined Jul 2014
Total Posts : 26
   Posted 9/1/2014 6:01 PM (GMT -6)   
Prilosec worked well for me the first time around.

If you can get carafate suspension, I recommend it.

Veteran Member

Date Joined Mar 2014
Total Posts : 1397
   Posted 9/2/2014 1:42 PM (GMT -6)   
Do you take the medication daily, or just when you feel that you need it? I know that it takes a while for the medication to take effect. Before my Nissen surgery, I took Protonix as it was the only medication that gave me relief. A lot of people on this board swear by the sulcrafate suspension, it's worth a try. I'm one of the few that it did absolutely nothing for.

Veteran Member

Date Joined Oct 2009
Total Posts : 5013
   Posted 9/2/2014 4:29 PM (GMT -6)   
You have to take PPIs first thing when you get up, then eat something half an hour to an hour later or it won't work right.

PPIs have to get to the small intestine, which is why the granules in the capsules are enteric coated. They don't work in the acid stomach!

Then they have to get digested, get into the blood stream and get to the back side of the acid pumps to shut them off. The pumps have to be active to get shut off, which is why you eat something half an hour to an hour after taking the PPI.

(Rule of thumb - medicines that have to be digested need about 45 minutes to work.)

These things don't really work 24 hours. You may be able to find a table of "duration of action" online.

I got best results from Nexium 40mg and Aciphex. I tried all the other old ones and they didn't work well for me. Since Toupet surgery I haven't needed any.

Forum Moderator

Date Joined Feb 2009
Total Posts : 7185
   Posted 9/2/2014 10:01 PM (GMT -6)   
Hi BarbaraA,

Like you, I have a very sensitive/reactive stomach. In fact, before my Nissen surgery, I was hospitalized with terrible gastritis and esophagitis what caused my asthma to be out of control. My stomach was so bad I couldn't tolerate anything other than water and egg custard.

While my Nissen surgery has protected my esophagus, my sensitive/reactive stomach is still with me. When I have a flare, I use Protonix 40mg an hour before breakfast and an hour before dinner. This helps protect my stomach lining from acid. I have found Prilosec, Nexium, and Protonix to be pretty much equal, but the GI doc put me on the Protonix after that hospitalization.

It's important to take the PPI properly to get the best results. Here's a link to a document that discusses how PPIs use, and how to get the most out of them:

With my sensitive stomach, I am never without Carafate (sulcrafate) suspension. I find it provides comfort/pain relief, and aids in healing. It's tricky to get all four doses in because it has to be two hours before or after medication and/or meals. It helps to plan it out so you can take a dose before bedtime, and a dose when/if you wake up in the middle of the night or early in the morning. The suspension form is expensive. If your insurance doesn't cover it, you can try the sulcrafate tablets. I've done that can put the tablet in a medicine cup or shot glass and add a little water...stir with a toothpick, then throw it back like a shot. Still, if you can swing the Carafate suspension, I think it's best.

Healing gastritis takes time and patience. PPIs don't start really working at full effectiveness for a week or so. My GI doc told me (when I asked him when I could eat normally after gastritis) he said to wait until my stomach feels perfect, for two weeks. Then you can introduce more challenging foods back into your diet gradually.

Hang in will get feeling better, but it takes a long time.

est wishes,

GERD/Heartburn Moderator
Nissen Fundoplication 2/09

"Whatever you fight, you strengthen, and what you resist, persists.”

“Worry pretends to be necessary but serves no useful purpose”

“Accept - then act. Whatever the present moment contains, accept it as if you had chosen it. Always work with it, not against it.”
Eckhart Tolle

Veteran Member

Date Joined Dec 2012
Total Posts : 1177
   Posted 9/8/2014 10:20 AM (GMT -6)   
For immediate relief it is better to have an ant-acid like Gaviscon to hand, that will instantly neutralise acid giving time for the PPI to kick in and stop further production.

Have you tried relaxation? I found it helped my symptoms even though they weren't caused by stress (but were made worse by it)

Oh and for nausea I highly recommend ginger capsules, I couldnt live without them!
GERD, Anxiety, Depression, Rolling Hiatus Hernia, Esophageal Hypersensitivity

Regular Member

Date Joined Sep 2014
Total Posts : 49
   Posted 9/21/2014 10:51 PM (GMT -6)   
Barbara- I also have chronic gastritis and Prilosec didn't do any good for me. I just started taking nexium 3 days ago and I can definitely feel the difference, I barely have the burning pains or sharp pains in middle of stomach anymore. I also take carafate suspension along with dgl licorice, pepzin GI, slippery elm in between. I'd recommend all of these especially the slippery elm powder form, it soothes the stomach fast when you get the stomach pains. I've had this for over 6 months now and now I think I may have finally got the combination of meds I need to heal. I don't have any side effects with nexium either. Good luck, hope you get well

Veteran Member

Date Joined Dec 2012
Total Posts : 1177
   Posted 9/26/2014 1:00 PM (GMT -6)   
I find ginger capsules great for nausea and DGL helps with my stomach pain
GERD, Anxiety, Depression, Rolling Hiatus Hernia, Esophageal Hypersensitivity
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