Thanks for replying to my post.
I was told by my GI to take Pepsid at night for the nighttime breakthroughs of the gerd. Thats when it's at it's worst for me too. You can take Pepsid with Nexium. I take one right before bedtime and it works for 8 hours. It really does help me. Also I sleep sitting up. Those 6 inches that they say to elevate yourself is for the birds. Also Dr said not to eat anything 4-5 hours before bedtime. I also take DGL ( Licorice root) which does help soothe the esophagus. If you can stand the taste :)
And yes, Nexium can cause anemia, B12 deficiencies and other things. You can read up on it online. They tell you about the minor problems like headaches , diahreah, abdominal pain which are most common. There are many uncommon ones as well. It seems to be a problem with all the PPI's. Lots of medications can cause Anemia, not sure if Pepsid does though.
Will check out Primal Defense and see if it helps. I know that many IBS sufferers also have Gerd. Wish they would find a cure..they are close to a cure for Chrons now, but Gerd seems to be at the bottom of the chain. Should mention that I am female and going through the first stages of menopause. Night sweats, menstrual cycles at 21 days now...ohhhh,,, isn't life fun?