I have been on Nexium for just over a month, now and it finally kicked in! It takes FOREVER to work but it finally did work for me. You're supposed to not eat anything for AT LEAST AN HOUR AFTER YOU TAKE THE NEXIUM. So, I take my Nexium and I wait about 1.5 hours to eat. I take it at 10:00 and eat at 11:30. Yea, that's late but I have IBS too and have to take a bunch of other stuff starting at 7:00am!! LOL!! So, I dont' get to eat until almost noon!!!
So, If you're eating WITHIN 60 minutes of taking it, it's not getting into your system good enough. It will work, you just have to give it time, I guess. I still have breakthrough heartburn but it's not supposed to take FULL effect for 2-3 months according to my doctor. I don't have to take NEARLY THE AMOUNT OF ANTACIDS I used to have to take. I just take the occasional Pepto, now and I'm okay. I also eat alkaline foods, though to help control the PH in my body. I eat alot of mushrooms and potatoes and stay away from acidic foods like soda, meat, bread, rice, white flour products and sugar. It helps TREMENDOUSLY!!! If I eat sugar, I get instant reflux, still.
The other PPI's that I have been on worked almost instantly but I suffered side effects. The nexium takes FOREVER but I don't have any side effects. It's my last hope next to surgery to fix my hiatal hernia.
Keep us Posted!!