I have noticed that the PPI I'm currently taking seems to be losing its effectiveness too. I have been taking aciphex for 3.5 years. I started off with just 20 mg/day, but last year had it upped to 40 mg/day and I now supplement with 300 mg of zantac every night. I was told I would be on PPIs for life. Everytime I try to back off of them, the symptoms return 100 fold. I have never heard of PPIs only being temporary drugs. The Nissan Fudoplication surgery is also an option for severe GERD. However, I have read that the operation is only minimally successful for some, and then it's only a temporary effect. The surgery is not something I would seriously consider.
Current dx: Rheumatoid Arthritis
Suspected dx: Early Lupus/MCTD; Inflammatory Bowel Disease
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan