I, too, had allergies to the PPIs ( prevacid, prilosec...). It took me a while to figure it out and I was miserable in the meantime. As a nurse, I was looking into my disability plan at work. I had extreme joint pain, swelling, fatigue, dizziness. Even though I am thin, I was so swollen, I could move my kneecaps around and I could occasionally feel my internal organs shifting. I could barely walk. There were days I just laid in bed. Generally, I felt like I had the flu 24-7. I was living on Motrin--about 8 tablets a day. I had been sent to many doctors, but everything came back normal. One night, at about 0200, I was laying on the couch feeling like I needed to go to the ER because the spasms in my legs were so bad. about a week before I was driving and had to pull over because I could not keep my foot safely on the gas pedal because of the spasms. Anyway, at 0200, I had the notion to look up the side effects (rare) which are not posted on all the websites. The US websites do not make pharmaceutical companies disclose the rare side effects if <1% are effected. Look at the Canadian and UK websites for RARE side effects. It was like reading my laundry list of physical ailments. I quit taking the Prilosec and approximately 36 hours later I could actually feel my body returning to normal. I do not remember ever being so happy.
The GERD came back, too. With a vengence. I went to a gastroenterologist and told her I wanted a Nissen Fundoplication. It was one of the most wonderful things I have ever done. I would do it agin in a heartbeat. No GERD, no meds. The test to get the procedure is painful as they put a tube through your nose to your stomack while you ae awake and it monitors your acid for 24 hours. Good luck and Google non US websites for the rare side effects.