Gastric Acid Emptying linked to Relative Increase in Non-Acid Reflux..article

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sillylilly
Regular Member


Date Joined Oct 2006
Total Posts : 317
   Posted 2/21/2007 9:12 PM (GMT -6)   
NEW YORK (Reuters Health) Feb 12:  Continuing heartburn symptoms even with proton pump inhibitor treatment for GERD may be explained my a relative increase in non-acidic reflux events, researchers in Oklahoma suggest in the February issue of Chest.
 
Dr. Suanne Goodrich and her associates at the Lynn Health Science Institute in Oklahoma City point out that onon-acid reflux during sleep has not been evaluted.  They theorize that non-acid reflux during sleep could cause prolonged mucosal exposure to bile salts and pancreatic enzymes, and increase the risk of pulmonary aspiration.
 
In a crossover trial, 15 subjects with heartburn were assigned to treatment with 40mg Nexium for one week and to placebo for one week, in random order.
 
After a week of treatment, the subjects spent a night in the researchers' lab, where they under-went multichannel intraluminal impedance and PH monitoring during sleep.  Prior to going to bed, the subjectss ate pizza, brownies, and grape juice to increase the likelihood of reflux.
 
Treatment with Nexium reduced the rate of reflux episodes by approximately half (73 to 39 per night), but the number of non-acid reflux events rose from 6 to 27.
 
The team notes that reflux may cause arousal, which actually protects the esophagus by increasing salivation and swallowing.  They observed that most reflux events, either acidic or non-acidic, resulted in an arousal response within 2 minutes.
 
The fact that "the esophagus is equally responsive to acidic and non-acidic" indicates no increased risk of damage to the esophagus.  On the other hand, Dr. Goodrich and her associates maintain, "the relative increase in non-acidic reflux events may explain the per-
sistence of symptoms in some patients treated with proton pump inhibitors."
 
I found this interesting for all of us who seem to think that the PPI's aren't working some of the time.....Sillylilly

Tummytuck
Regular Member


Date Joined Jan 2007
Total Posts : 99
   Posted 2/22/2007 7:34 AM (GMT -6)   
Thanks for this information, sillylilly. Pizza, brownies, and grapejuice!?! That must have been fun. I wonder how one can distinguish between acid and non-acid reflux?

Tummytuck

Lonibel
Regular Member


Date Joined Jun 2006
Total Posts : 145
   Posted 2/22/2007 9:35 AM (GMT -6)   
Yes - thank you, Sillylilly. It's encouraging that someone is researching beyond "Take this little purple pill and eat whatever you want". Just to add to the mix, I ate an ITALIAN SAUSAGE on Sunday at church - was starving and nothing else there to eat - and had NO REFLUX. Can't figure this thing out.

Dee75
Regular Member


Date Joined Jul 2005
Total Posts : 247
   Posted 2/22/2007 10:25 PM (GMT -6)   
The doctor thinks I may have what is called, Silent reflux. I produce so much mucous during the night, but I don't have acid-reflux. They put me on Nexium. I was told it will take a few weeks before it works. I'm on the beginning of week two. I sure hope it's the answer. If not I think the may put me on allergy shots. Thanks for the article sillywilly,Dee

debaser
Veteran Member


Date Joined Nov 2006
Total Posts : 1745
   Posted 2/23/2007 1:14 PM (GMT -6)   
Lonibel said...
Yes - thank you, Sillylilly. It's encouraging that someone is researching beyond "Take this little purple pill and eat whatever you want". Just to add to the mix, I ate an ITALIAN SAUSAGE on Sunday at church - was starving and nothing else there to eat - and had NO REFLUX. Can't figure this thing out.


Yeah, I know the feeling. Sometimes I can whatever I want and there's no reflux at all. Occasionally, when I've been feeling poorly and eat something stupid (out of anger -- haha) I don't even feel it.

Other times, a freaking slice of bread will make me miserable.
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