It is possible to have nonacid reflux. I certainly do. I take a double dose of aciphex, and have for years. When I take my meds, I have minimal acid reflux (although breakthrough acid is common); however, I still have reflux. PPIs take care of the acid production, but they don't do anything for actual reflux. My reflux does travel up to my esophagus and messes with my voicebox; I am constantly clearing my throat. The only thing that helped with the actual reflux is reglan--it forced my esophagus to contract correctly to prevent my stomach contents from travel upwards. Short of surgery or drugs like reglan and propulsid, I'm not sure there's a whole lot that can be done about nonacid reflux (bile reflux).
Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan