It think it is very interesting the medication factor. If you back way off this part of the body and look at the body as a whole; people who diet, lose weight then eat again and gain weight, they usually gain more, weighing more than when they started. People who go on low-fat diets to bring down cholesterol and do so for quite a while, and go off the diet and eat something they really love but has a lot of fat, their body reacts with diarrhea for days. Or in the case of people whole are alcoholics or drug addicts that quit, maybe for years and then drink or use, they also assume like the person on the low-fat diet that they can have hamhaocks or pork ribs just like they used to, the addict/alcoholics drink and use like they used to and the body doesn't quite know what to do with strange element it hasn't seen for a while, they often O.D. and die. Our body is a machine, it requires certain vitimins, minerals, fiber, protein, and exercise for optimal fitness. It also produces all the necessary chemicals to process what "input" it gets. When you take something away for a period of time, your chemical body shifts it's chemical output to try and match, to continue a "normal" output. When you take it away, put it back, take it away, put it back, I think the body just says "I give up, I don't know what chemicals to produce to keep things level." I wonder what PPI's do to the chemistry of our bodies, does it deny us protein? Vitamins? Does our body get fooled into thinking it does not need to produce the chemical that best breaks down protein and calcium sending the necessary parts to the muscles and organs that give them optimal fuel? It's all so baffling. Sometimes I wonder if the East, which studied cause and effect, had the right idea that the body must tell you what is missing, where is there too much, trouble is I don't think we listen enough to our own bodies, we put our trust in Docs, who largely rely on drug companies because, for so long, we just wanted a quick fix. I know I've been guilty of that, I don't care what it is, just fix it, it hurts! I know I have been using fat free mayonaise for tens years, if I have a tuna sandwich away from home and they use real mayonaise, my stomach rumbles and I feel nauseous. I wish they could nail down once and for all, what causes GERD, Reflux, and acid stomach. My husband is a stress puppy, always has been. The last few years have been particluarly stressful for both of us. Yet he claims stress has nothing to do with GERD. I don't see of it can't be! If stressed, you produce more stomach acid, if you don't put, either enough of, or the right kind of food to soak, or use it up, it will stay in your stomach, cooking, waiting to do something, and if you lay down, it starts eating at your sphincter, soon you have nothing to separate your stomach and esophogus, and laying down always goes to your throat. Goollee, you can sure tell it's Sunday, too much time to sit here, better go make another stomach safe dinner.